Ruthenium(II) complexes of curcumin and β-diketone derivatives: effect of structural modifications on their cytotoxicity

Ruthenium(II) complexes ( - ) with the general formula [Ru(O-O)(PPh ) (bipy)]PF bearing two triphenylphosphine (PPh ), bipyridine (bipy) and a series of natural and synthetic β-diketones (O,O) ligands were synthesized and characterized using various analytical techniques. The interaction between the...

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Bibliographic Details
Published in:Royal Society open science 2024-07, Vol.11 (7), p.240353
Main Authors: Jacinto, Flávia E, de Oliveira, Letícia Pires, Batista, Alzir A, Oliveira, Katia M, Correa, Rodrigo S
Format: Article
Language:English
Subjects:
antitumour
Chemistry
curcumin
DNA
metallodrug
ruthenium(II) complexes
β-diketones
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Summary:Ruthenium(II) complexes ( - ) with the general formula [Ru(O-O)(PPh ) (bipy)]PF bearing two triphenylphosphine (PPh ), bipyridine (bipy) and a series of natural and synthetic β-diketones (O,O) ligands were synthesized and characterized using various analytical techniques. The interaction between the complexes and DNA (CT-DNA) was investigated and demonstrated a weak interaction. The cytotoxicity of the complexes was investigated against breast cancer cells (MDA-MB-231 and MCF-7), lung cancer cells (A549), cisplatin-resistant ovarian cancer cells (A2780 ), as well as non-tumour lung (MRC-5) and non-tumour breast (MCF-10A) cell lines. All complexes exhibited cytotoxic activity against all the cell lines studied, with half maximal inhibitory concentration (IC ) values ranging from 0.39 to 13 µM. Notably, the three complexes demonstrated selectivity against the A2780 cell line, with IC ranging from 0.39 to 0.82 µM. Among them, Ru2 exhibited the highest cytotoxicity, with an IC value of 0.39 µM. Consequently, this new class of complexes shows good selectivity towards cisplatin-resistant ovarian cancer cells and it is promising for further investigation as anti-cancer agents.
ISSN:2054-5703
2054-5703
DOI:10.1098/rsos.240353