Nickel catalyzed multicomponent stereodivergent synthesis of olefins enabled by electrochemistry, photocatalysis and photo-electrochemistry

Trisubstituted alkenes are important organic synthons and have broad applications in the synthesis of many pharmaceuticals and materials. The stereoselective synthesis of such compounds has long been a research focus for organic researchers. Herein, we report a three-component, reductive cascade, cr...

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Bibliographic Details
Published in:Nature communications 2022-06, Vol.13 (1), p.3240-3240, Article 3240
Main Authors: Zhu, Chen, Yue, Huifeng, Rueping, Magnus
Format: Article
Language:English
Subjects:
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Alkenes
Alkynes
Catalysts
Chemical reactions
Chemical synthesis
Cross coupling
Electrochemistry
Humanities and Social Sciences
Isomers
multidisciplinary
Nickel
Photocatalysis
Photochemistry
Photoelectrochemistry
Science
Science (multidisciplinary)
Stereoselectivity
Switching
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Summary:Trisubstituted alkenes are important organic synthons and have broad applications in the synthesis of many pharmaceuticals and materials. The stereoselective synthesis of such compounds has long been a research focus for organic researchers. Herein, we report a three-component, reductive cascade, cross-coupling reaction for the arylalkylation of alkynes. A wide range of trisubstituted alkenes are obtained in good to high yields with excellent chemo- and stereoselectivity by switching between electrochemistry and photocatalysis. The E isomer of the product is obtained exclusively when the reaction is conducted with electricity and nickel, while the Z isomer is generated with high stereoselectivity when photo- and nickel dual catalysts are used. Moreover, photo-assisted electrochemically enabled nickel catalyzed protocol is demonstrated to selectively deliver Z -trisubstituted alkenes without the addition of photocatalysts. The construction of trisubstituted alkenes with high stereoselectivity is challenging. Here, the authors realize the stereodivergent synthesis of such compounds via switching between electrochemistry, photochemistry and photoelectrochemistry.
ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-022-30985-2