Synthesis and Antimicrobial Evaluation of Certain Novel Thiazoles

Purpose: This article makes an attempt to synthesize certain compounds containing thiazole and imidazole moieties and screen for the antimicrobial properties. Methods: The novel compounds synthesized were characterized by elemental analysis, IR and 1 HNMR spectral data. The antimicrobial activity of...

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Bibliographic Details
Published in:Advanced pharmaceutical bulletin 2013, Vol.3 (1), p.227-230
Main Authors: Sreedevi, Meesaraganda, Guru Prasad, Aluru Raghavendra, Spoorthy, Yadati Narasimha, Ravindranath, Lakshmana Rao Krishna Rao
Format: Article
Language:English
Subjects:
Antimicrobial activity
Characterization
Imidazole moiety
Synthesis
Thiazole moiety
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Summary:Purpose: This article makes an attempt to synthesize certain compounds containing thiazole and imidazole moieties and screen for the antimicrobial properties. Methods: The novel compounds synthesized were characterized by elemental analysis, IR and 1 HNMR spectral data. The antimicrobial activity of novel compounds was evaluated by cup plate method. Results: The compound p-t showed more antibacterial activity than that of the standard. p-hp and p-as showed considerable antibacterial activity. p-t demonstrated higher antifungal activity than that of the standard while p-hp and p-as showed considerable antifungal activity. Conclusion: The antimicrobial activity studies were conducted on certain selected bacteria and fungi. In each case antimicrobial activity of the compounds was compared with that of standards. p-t, p-hp, p-np, p-cp, p-ts and p-as showed considerable antimicrobial activity.
ISSN:2228-5881
2251-7308
DOI:10.5681/apb.2013.037