Ankfy1 Is Involved in the Maintenance of Cerebellar Purkinje Cells

Purkinje cells are critical for the function of cerebellum. The degeneration of Purkinje cells leads to defects in motion control. We have found that Purkinje cells specifically express Ankfy1 protein during development and in adult. This protein seems to play minor functions during development as A...

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Bibliographic Details
Published in:Frontiers in cellular neuroscience 2021-03, Vol.15, p.648801-648801
Main Authors: Chang, Liansheng, Soomro, Shahid Hussain, Zhang, Hongfeng, Fu, Hui
Format: Article
Language:English
Subjects:
Ankfy1
Antibodies
ataxia
Cellular Neuroscience
Cerebellum
Degeneration
Experiments
Hybridization
Laboratory animals
Morphology
Proteins
Purkinje cells
Rodents
Young adults
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Summary:Purkinje cells are critical for the function of cerebellum. The degeneration of Purkinje cells leads to defects in motion control. We have found that Purkinje cells specifically express Ankfy1 protein during development and in adult. This protein seems to play minor functions during development as Ankfy1 knockout mice appear normal till adult. However, at 9-month-old, knockout mice showed abnormal cerebellum with reduced vermis size and developed defective motor function. Further investigation demonstrated that the cerebellum of the mutant mouse has lost most of its Purkinje cells, while other cerebellar cells remained largely normal. Our data suggested that the might be important for the maintenance of cerebellar Purkinje cells.
ISSN:1662-5102
1662-5102
DOI:10.3389/fncel.2021.648801