Resveratrol and 2-Ethyl-6-Methyl-3-Hydroxypiridine N-Acetyl Cysteinate as Protecting Agents upon the Stress Exposure

The increased generation of reactive oxygen species (ROS) by mitochondria under stress conditions leads to lipid peroxidation (LPO) as a consequence of the ROS interactions with polyunsaturated fatty acids in the lipid bilayer of cell membranes, causing their damage. It was assumed that chemical pre...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-08, Vol.24 (17), p.13172
Main Authors: Zhigacheva, Irina V, Rusina, Irina F, Krikunova, Natalia I, Goloschapov, Aleksandr N, Veprintsev, Timur L, Yablonskaya, Olga I, Trofimov, Aleksei V
Format: Article
Language:English
Subjects:
Aging
Alcohol
Antioxidants
Antioxidants - pharmacology
bioantioxidants
Cell Membrane
chemiluminescence assay
Free radicals
Hydrocarbons
Hypoxia
Lipid Bilayers
Membrane lipids
Mitochondria
Oxidation
Oxidative stress
Physiological aspects
Poisoning
Polyunsaturated fatty acids
Proteins
Reactive Oxygen Species
Resveratrol
Resveratrol - pharmacology
ROS generation and scavenging
Unsaturated fatty acids
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Summary:The increased generation of reactive oxygen species (ROS) by mitochondria under stress conditions leads to lipid peroxidation (LPO) as a consequence of the ROS interactions with polyunsaturated fatty acids in the lipid bilayer of cell membranes, causing their damage. It was assumed that chemical preparations that reduce the excessive ROS generation by mitochondria should exhibit protecting properties under oxidative-stress conditions. In this context, the antioxidants resveratrol (RSV) and 2-ethyl-6-methyl-3-hydroxypyridine N-acetylcysteinate (NAC-3-HP) were examined as potential chemical protectors upon the exposure to stress, able to maintain the functional state of mitochondria.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms241713172