Location of mechanically-evoked referred sensations within the trigeminal region are not altered following a heterotopic painful stimulus

To investigate whether the location, area and frequency of referred sensations occurring during palpation of the masseter muscle can be influenced by application of a conditioning painful stimulus to the temporalis muscle. Thirty healthy participants were included in this cross-over study, performed...

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Bibliographic Details
Published in:Scientific reports 2022-12, Vol.12 (1), p.21181-21181, Article 21181
Main Authors: Exposto, Fernando G., Huang, Miranda, Haasnoot, Talita, Koutris, Michail, Lobbezoo, Frank, Bendixen, Karina H., Svensson, Peter
Format: Article
Language:English
Subjects:
631/378/2620/410
692/698/3008/3013
Cross-Over Studies
Dentistry
Experiments
Glutamic Acid
Humanities and Social Sciences
Humans
Injection
Masseter muscle
Mechanical stimuli
multidisciplinary
Oral hygiene
Pain
Science
Science (multidisciplinary)
Sensation
Social networks
Temporalis muscle
Temporomandibular joint disorders
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Summary:To investigate whether the location, area and frequency of referred sensations occurring during palpation of the masseter muscle can be influenced by application of a conditioning painful stimulus to the temporalis muscle. Thirty healthy participants were included in this cross-over study, performed in two sessions with > 48 h in between. At each session, palpation of the masseter muscle was performed before and after 0.2 ml of glutamate (1 mol/L) or isotonic saline (control) were injected into the anterior portion of the temporalis muscle. Palpation of the masseter muscle was done using four different forces (0.5 kg, 1 kg, 2 kg and 4 kg). Participants rated the perceived intensity of the palpation and any referred sensations on a 0–50–100 numeric rating scale, the perceived pain intensity following the injections on an electronic visual analogue scale and drew any referred sensations they experienced. No difference in referred sensations location, area and frequency was shown r during palpation either before or after injections ( P  > 0.05). A moderate correlation was found between perceived sensation scores and referred sensations intensity for the temporalis muscle following glutamate injection ( r  = 0.407, P  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-24510-0