Dopamine Modulates the Processing of Food Odour in the Ventral Striatum

Food odour is a potent stimulus of food intake. Odour coding in the brain occurs in synergy or competition with other sensory information and internal signals. For eliciting feeding behaviour, food odour coding has to gain signification through enrichment with additional labelling in the brain. Sinc...

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Bibliographic Details
Published in:Biomedicines 2022-05, Vol.10 (5), p.1126
Main Authors: Rampin, Olivier, Saint Albin Deliot, Audrey, Ouali, Christian, Burguet, Jasmine, Gry, Elisa, Champeil Potokar, Gaelle, Jérôme, Nathalie, Davidenko, Olga, Darcel, Nicolas, Bombail, Vincent, Andrey, Philippe, Denis, Isabelle
Format: Article
Language:English
Subjects:
Cognitive science
Dopamine
Dopamine D1 receptors
Dopamine D2 receptors
Drug dosages
Electrodes
Feeding behavior
Food
Food intake
food odour
Food processing
Information processing
Innervation
Labeling
Localization
Metabolism
Neostriatum
Neural coding
Neuroscience
Odor
Population
Raclopride
Reinforcement
Respiration
Rhythms
ventral striatum
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Summary:Food odour is a potent stimulus of food intake. Odour coding in the brain occurs in synergy or competition with other sensory information and internal signals. For eliciting feeding behaviour, food odour coding has to gain signification through enrichment with additional labelling in the brain. Since the ventral striatum, at the crossroads of olfactory and reward pathways, receives a rich dopaminergic innervation, we hypothesized that dopamine plays a role in food odour information processing in the ventral striatum. Using single neurones recordings in anesthetised rats, we show that some ventral striatum neurones respond to food odour. This neuronal network displays a variety of responses (excitation, inhibition, rhythmic activity in phase with respiration). The localization of recorded neurones in a 3-dimensional brain model suggests the spatial segregation of this food-odour responsive population. Using local field potentials recordings, we found that the neural population response to food odour was characterized by an increase of power in the beta-band frequency. This response was modulated by dopamine, as evidenced by its depression following administration of the dopaminergic D1 and D2 antagonists SCH23390 and raclopride. Our results suggest that dopamine improves food odour processing in the ventral striatum.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines10051126