Biomimetic Enamel Regeneration Using Self-Assembling Peptide P11-4

The recent understanding of the etiology and pathology of dental caries has shifted its treatment from invasive drill and fill conventional strategies to noninvasive and/or minimally invasive approaches. Guided tissue regeneration (GTR) is a well-established therapeutic approach in medicine and peri...

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Bibliographic Details
Published in:Biomimetics (Basel, Switzerland) Switzerland), 2023-07, Vol.8 (3), p.290
Main Authors: Alkilzy, Mohammad, Qadri, Ghalib, Splieth, Christian H., Santamaría, Ruth M.
Format: Article
Language:English
Subjects:
Amino acids
Biocompatibility
Biofilms
Biomaterials
biomimetic
Dental caries
Dental enamel
Dentistry
Dentists
Dietary minerals
enamel regeneration
Fluorides
Hydroxyapatite
initial caries
Net losses
P11-4
Peptides
Physiology
Remineralization
Review
self-assembling peptide
Toothpaste
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Summary:The recent understanding of the etiology and pathology of dental caries has shifted its treatment from invasive drill and fill conventional strategies to noninvasive and/or minimally invasive approaches. Guided tissue regeneration (GTR) is a well-established therapeutic approach in medicine and periodontal and oral surgery. Recently, the concept of biomimetic regeneration has been further expanded to treat the loss of hard dental tissues. Self-assembling peptides have emerged as a promising biomaterial for biomimetic regeneration due to their ability to construct a protein scaffold in the body of early carious lesions and provide a matrix that promotes remineralization. This review article accompanies the development of self-assembling peptide P11-4 for the treatment of initial carious lesions. In vitro and in vivo studies on the safety, clinical applicability, and efficacy of P11-4 are discussed. Furthermore, different treatment options and potential areas of application are presented.
ISSN:2313-7673
2313-7673
DOI:10.3390/biomimetics8030290