Dual mechanism of chromatin remodeling in the common shrew sex trivalent (XY 1 Y 2 )

Here we focus on the XY Y condition in male common shrew Linnaeus, 1758, applying electron microscopy and immunocytochemistry for a comprehensive analysis of structure, synapsis and behaviour of the sex trivalent in pachytene spermatocytes. The pachytene sex trivalent consists of three distinct part...

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Bibliographic Details
Published in:Comparative cytogenetics 2017, Vol.11 (4), p.727-745
Main Authors: Matveevsky, Sergey N, Pavlova, Svetlana V, Atsaeva, Maret M, Searle, Jeremy B, Kolomiets, Oxana L
Format: Article
Language:English
Subjects:
Alliances
Chromatin remodeling
Chromosomes
Deactivation
Domains
Electron microscopy
Immunocytochemistry
Inactivation
Meiosis
Pachytene
Proteins
Sex
Sex chromosomes
Sexual behavior
Spermatocytes
Topology
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Summary:Here we focus on the XY Y condition in male common shrew Linnaeus, 1758, applying electron microscopy and immunocytochemistry for a comprehensive analysis of structure, synapsis and behaviour of the sex trivalent in pachytene spermatocytes. The pachytene sex trivalent consists of three distinct parts: short and long synaptic SC fragments (between the X and Y and between the X and Y , respectively) and a long asynaptic region of the X in-between. Chromatin inactivation was revealed in the XY synaptic region, the asynaptic region of the X and a very small asynaptic part of the Y . This inactive part of the sex trivalent, that we named the 'head', forms a typical sex body and is located at the periphery of the meiotic nucleus at mid pachytene. The second part or 'tail', a long region of synapsis between the X and Y chromosomes, is directed from the periphery into the nucleus. Based on the distribution patterns of four proteins involved in chromatin inactivation, we propose a model of meiotic silencing in shrew sex chromosomes. Thus, we conclude that pachytene sex chromosomes are structurally and functionally two different chromatin domains with specific nuclear topology: the peripheral inactivated 'true' sex chromosome regions (part of the X and the Y ) and more centrally located transcriptionally active autosomal segments (part of the X and the Y ).
ISSN:1993-0771
1993-078X
DOI:10.3897/CompCytogen.v11i4.13870