Loading…
Differentiating Left Atrial Pressure Responses in Paroxysmal and Persistent Atrial Fibrillation: Implications for Diagnosing Heart Failure With Preserved Ejection Fraction and Managing Atrial Fibrillation
Increased left atrial pressure (LAP) contributes to dyspnea and heart failure with preserved ejection fraction in patients with atrial fibrillation (AF). The purpose of this study was to investigate the differences in baseline LAP and LAP response to rapid pacing between paroxysmal and persistent AF...
Saved in:
| Published in: | Journal of the American Heart Association 2024-09, Vol.13 (17), p.e035246 |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | |
|---|---|
| cites | cdi_FETCH-LOGICAL-c303t-f3e2ff7450692a6d86f254691215afde761ac299d913a1253ff89a05d2c7859e3 |
| container_end_page | |
| container_issue | 17 |
| container_start_page | e035246 |
| container_title | Journal of the American Heart Association |
| container_volume | 13 |
| creator | Park, Jong Sung Cho, Iksung Kim, Daehoon Kim, Moon-Hyun Park, Je-Wook Yu, Hee Tae Kim, Tae-Hoon Uhm, Jae-Sun Joung, Boyoung Lee, Moon-Hyoung Pak, Hui-Nam |
| description | Increased left atrial pressure (LAP) contributes to dyspnea and heart failure with preserved ejection fraction in patients with atrial fibrillation (AF). The purpose of this study was to investigate the differences in baseline LAP and LAP response to rapid pacing between paroxysmal and persistent AF.
This observational study prospectively enrolled 1369 participants who underwent AF catheter ablation, excluding those with reduced left ventricular ejection fraction. H
FPEF score was calculated by echocardiography and baseline characteristics. Patients underwent LAP measurements during AF, sinus rhythm, and heart rates of 90, 100, 110, and 120 beats per minute (bpm), induced by right atrial pacing and isoproterenol. The baseline LAP-peak in the persistent AF group consistently exceeded that in the paroxysmal AF (PAF) group across each H
FPEF score subgroup (all |
| doi_str_mv | 10.1161/JAHA.124.035246 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_677cab0225aa45ff9b06638f4b80bdd9</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_677cab0225aa45ff9b06638f4b80bdd9</doaj_id><sourcerecordid>3097495421</sourcerecordid><originalsourceid>FETCH-LOGICAL-c303t-f3e2ff7450692a6d86f254691215afde761ac299d913a1253ff89a05d2c7859e3</originalsourceid><addsrcrecordid>eNptkl9v0zAUxSMEYtPYM2_Ij7y08784MS-o2lZaVESFQDxaN8l15yqNi51O23fkQ-E027RJ-MXX9j2_Y1sny94zOmVMsYuvs8VsyricUpFzqV5lp5zKYqJ1SV8_q0-y8xi3NA3FC5Hrt9mJ0KzUshCn2d8rZy0G7HoHves2ZIW2J7M-OGjJOmCMh4DkB8a97yJG4jqyhuDv7uMuNUDXkDWG6GKfCI-yuauCa9vE890nstztW1cfF5FYH8iVg03n42C2QAg9mYNrB5ffrr85emK4xYZcb7EeVGQeYCwGu2_QwWbQ_sfsXfbGQhvx_GE-y37Nr39eLiar71-Wl7PVpBZU9BMrkFtbyJwqzUE1pbI8l0ozznKwDRaKQc21bjQTwHgurC010LzhdVHmGsVZthy5jYet2Qe3g3BvPDhz3PBhY9K7XN2iUUVRQ0U5zwFkbq2uqFKitLIqadU0OrE-j6z9odphU6d_DNC-gL486dyN2fhbkyIgldRFInx8IAT_54CxNzsXa0x_0qE_RCOoLqTOJWep9WJsrYOPMaB98mF0ADIzZMqkTJkxU0nx4fn1nvofEyT-AQ1rzJc</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3097495421</pqid></control><display><type>article</type><title>Differentiating Left Atrial Pressure Responses in Paroxysmal and Persistent Atrial Fibrillation: Implications for Diagnosing Heart Failure With Preserved Ejection Fraction and Managing Atrial Fibrillation</title><source>Wiley Online Library Open Access</source><source>PubMed Central</source><creator>Park, Jong Sung ; Cho, Iksung ; Kim, Daehoon ; Kim, Moon-Hyun ; Park, Je-Wook ; Yu, Hee Tae ; Kim, Tae-Hoon ; Uhm, Jae-Sun ; Joung, Boyoung ; Lee, Moon-Hyoung ; Pak, Hui-Nam</creator><creatorcontrib>Park, Jong Sung ; Cho, Iksung ; Kim, Daehoon ; Kim, Moon-Hyun ; Park, Je-Wook ; Yu, Hee Tae ; Kim, Tae-Hoon ; Uhm, Jae-Sun ; Joung, Boyoung ; Lee, Moon-Hyoung ; Pak, Hui-Nam</creatorcontrib><description>Increased left atrial pressure (LAP) contributes to dyspnea and heart failure with preserved ejection fraction in patients with atrial fibrillation (AF). The purpose of this study was to investigate the differences in baseline LAP and LAP response to rapid pacing between paroxysmal and persistent AF.
This observational study prospectively enrolled 1369 participants who underwent AF catheter ablation, excluding those with reduced left ventricular ejection fraction. H
FPEF score was calculated by echocardiography and baseline characteristics. Patients underwent LAP measurements during AF, sinus rhythm, and heart rates of 90, 100, 110, and 120 beats per minute (bpm), induced by right atrial pacing and isoproterenol. The baseline LAP-peak in the persistent AF group consistently exceeded that in the paroxysmal AF (PAF) group across each H
FPEF score subgroup (all
<0.05). LAP-peak increased with pacing (19.5 to 22.5 mm Hg) but decreased with isoproterenol (20.4 to 18.4 mm Hg). Under pacing, patients with PAF exhibited a significantly lower LAP-peak (90 bpm) than those with persistent AF (17.7±8.2 versus 21.1±9.3 mm Hg,
<0.001). However, there was no difference in LAP-peak (120 bpm) between the 2 groups (22.1±8.1 versus 22.9±8.4 mm Hg,
=0.056) because the LAP-peak significantly increased with heart rate in the group with PAF.
Patients with PAF exhibited lower baseline LAP with greater increases during rapid pacing compared with individuals with persistent AF, indicating a need to revise the H
FPEF score for distinguishing PAF from persistent AF and emphasizing the importance of rate and rhythm control in PAF for symptom control.
URL: https://www.clinicaltrials.gov; Unique Identifier: NCT02138695.</description><identifier>ISSN: 2047-9980</identifier><identifier>EISSN: 2047-9980</identifier><identifier>DOI: 10.1161/JAHA.124.035246</identifier><identifier>PMID: 39189473</identifier><language>eng</language><publisher>England: John Wiley and Sons Inc</publisher><subject>Aged ; atrial fibrillation ; Atrial Fibrillation - diagnosis ; Atrial Fibrillation - physiopathology ; Atrial Fibrillation - surgery ; Atrial Fibrillation - therapy ; Atrial Function, Left - physiology ; Atrial Pressure - physiology ; Cardiac Pacing, Artificial ; Catheter Ablation ; Echocardiography ; Female ; H2FPEF score ; Heart Failure - diagnosis ; Heart Failure - physiopathology ; Heart Failure - therapy ; Heart Rate - physiology ; Humans ; isoproterenol ; Isoproterenol - administration & dosage ; left atrial pressure ; Male ; Middle Aged ; Original Research ; pacing ; Prospective Studies ; Stroke Volume - physiology ; Ventricular Function, Left - physiology</subject><ispartof>Journal of the American Heart Association, 2024-09, Vol.13 (17), p.e035246</ispartof><rights>2024 The Author(s). Published on behalf of the American Heart Association, Inc., by Wiley.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c303t-f3e2ff7450692a6d86f254691215afde761ac299d913a1253ff89a05d2c7859e3</cites><orcidid>0000-0002-9736-450X ; 0000-0003-4200-3456 ; 0000-0002-7268-0741 ; 0000-0002-5311-4744 ; 0000-0002-6835-4759 ; 0000-0002-1611-8172 ; 0000-0002-6608-9816 ; 0000-0001-9036-7225 ; 0000-0001-8594-5983 ; 0000-0002-3256-3620 ; 0000-0001-5927-5410</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11646497/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11646497/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39189473$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, Jong Sung</creatorcontrib><creatorcontrib>Cho, Iksung</creatorcontrib><creatorcontrib>Kim, Daehoon</creatorcontrib><creatorcontrib>Kim, Moon-Hyun</creatorcontrib><creatorcontrib>Park, Je-Wook</creatorcontrib><creatorcontrib>Yu, Hee Tae</creatorcontrib><creatorcontrib>Kim, Tae-Hoon</creatorcontrib><creatorcontrib>Uhm, Jae-Sun</creatorcontrib><creatorcontrib>Joung, Boyoung</creatorcontrib><creatorcontrib>Lee, Moon-Hyoung</creatorcontrib><creatorcontrib>Pak, Hui-Nam</creatorcontrib><title>Differentiating Left Atrial Pressure Responses in Paroxysmal and Persistent Atrial Fibrillation: Implications for Diagnosing Heart Failure With Preserved Ejection Fraction and Managing Atrial Fibrillation</title><title>Journal of the American Heart Association</title><addtitle>J Am Heart Assoc</addtitle><description>Increased left atrial pressure (LAP) contributes to dyspnea and heart failure with preserved ejection fraction in patients with atrial fibrillation (AF). The purpose of this study was to investigate the differences in baseline LAP and LAP response to rapid pacing between paroxysmal and persistent AF.
This observational study prospectively enrolled 1369 participants who underwent AF catheter ablation, excluding those with reduced left ventricular ejection fraction. H
FPEF score was calculated by echocardiography and baseline characteristics. Patients underwent LAP measurements during AF, sinus rhythm, and heart rates of 90, 100, 110, and 120 beats per minute (bpm), induced by right atrial pacing and isoproterenol. The baseline LAP-peak in the persistent AF group consistently exceeded that in the paroxysmal AF (PAF) group across each H
FPEF score subgroup (all
<0.05). LAP-peak increased with pacing (19.5 to 22.5 mm Hg) but decreased with isoproterenol (20.4 to 18.4 mm Hg). Under pacing, patients with PAF exhibited a significantly lower LAP-peak (90 bpm) than those with persistent AF (17.7±8.2 versus 21.1±9.3 mm Hg,
<0.001). However, there was no difference in LAP-peak (120 bpm) between the 2 groups (22.1±8.1 versus 22.9±8.4 mm Hg,
=0.056) because the LAP-peak significantly increased with heart rate in the group with PAF.
Patients with PAF exhibited lower baseline LAP with greater increases during rapid pacing compared with individuals with persistent AF, indicating a need to revise the H
FPEF score for distinguishing PAF from persistent AF and emphasizing the importance of rate and rhythm control in PAF for symptom control.
URL: https://www.clinicaltrials.gov; Unique Identifier: NCT02138695.</description><subject>Aged</subject><subject>atrial fibrillation</subject><subject>Atrial Fibrillation - diagnosis</subject><subject>Atrial Fibrillation - physiopathology</subject><subject>Atrial Fibrillation - surgery</subject><subject>Atrial Fibrillation - therapy</subject><subject>Atrial Function, Left - physiology</subject><subject>Atrial Pressure - physiology</subject><subject>Cardiac Pacing, Artificial</subject><subject>Catheter Ablation</subject><subject>Echocardiography</subject><subject>Female</subject><subject>H2FPEF score</subject><subject>Heart Failure - diagnosis</subject><subject>Heart Failure - physiopathology</subject><subject>Heart Failure - therapy</subject><subject>Heart Rate - physiology</subject><subject>Humans</subject><subject>isoproterenol</subject><subject>Isoproterenol - administration & dosage</subject><subject>left atrial pressure</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Original Research</subject><subject>pacing</subject><subject>Prospective Studies</subject><subject>Stroke Volume - physiology</subject><subject>Ventricular Function, Left - physiology</subject><issn>2047-9980</issn><issn>2047-9980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNptkl9v0zAUxSMEYtPYM2_Ij7y08784MS-o2lZaVESFQDxaN8l15yqNi51O23fkQ-E027RJ-MXX9j2_Y1sny94zOmVMsYuvs8VsyricUpFzqV5lp5zKYqJ1SV8_q0-y8xi3NA3FC5Hrt9mJ0KzUshCn2d8rZy0G7HoHves2ZIW2J7M-OGjJOmCMh4DkB8a97yJG4jqyhuDv7uMuNUDXkDWG6GKfCI-yuauCa9vE890nstztW1cfF5FYH8iVg03n42C2QAg9mYNrB5ffrr85emK4xYZcb7EeVGQeYCwGu2_QwWbQ_sfsXfbGQhvx_GE-y37Nr39eLiar71-Wl7PVpBZU9BMrkFtbyJwqzUE1pbI8l0ozznKwDRaKQc21bjQTwHgurC010LzhdVHmGsVZthy5jYet2Qe3g3BvPDhz3PBhY9K7XN2iUUVRQ0U5zwFkbq2uqFKitLIqadU0OrE-j6z9odphU6d_DNC-gL486dyN2fhbkyIgldRFInx8IAT_54CxNzsXa0x_0qE_RCOoLqTOJWep9WJsrYOPMaB98mF0ADIzZMqkTJkxU0nx4fn1nvofEyT-AQ1rzJc</recordid><startdate>20240903</startdate><enddate>20240903</enddate><creator>Park, Jong Sung</creator><creator>Cho, Iksung</creator><creator>Kim, Daehoon</creator><creator>Kim, Moon-Hyun</creator><creator>Park, Je-Wook</creator><creator>Yu, Hee Tae</creator><creator>Kim, Tae-Hoon</creator><creator>Uhm, Jae-Sun</creator><creator>Joung, Boyoung</creator><creator>Lee, Moon-Hyoung</creator><creator>Pak, Hui-Nam</creator><general>John Wiley and Sons Inc</general><general>Wiley</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-9736-450X</orcidid><orcidid>https://orcid.org/0000-0003-4200-3456</orcidid><orcidid>https://orcid.org/0000-0002-7268-0741</orcidid><orcidid>https://orcid.org/0000-0002-5311-4744</orcidid><orcidid>https://orcid.org/0000-0002-6835-4759</orcidid><orcidid>https://orcid.org/0000-0002-1611-8172</orcidid><orcidid>https://orcid.org/0000-0002-6608-9816</orcidid><orcidid>https://orcid.org/0000-0001-9036-7225</orcidid><orcidid>https://orcid.org/0000-0001-8594-5983</orcidid><orcidid>https://orcid.org/0000-0002-3256-3620</orcidid><orcidid>https://orcid.org/0000-0001-5927-5410</orcidid></search><sort><creationdate>20240903</creationdate><title>Differentiating Left Atrial Pressure Responses in Paroxysmal and Persistent Atrial Fibrillation: Implications for Diagnosing Heart Failure With Preserved Ejection Fraction and Managing Atrial Fibrillation</title><author>Park, Jong Sung ; Cho, Iksung ; Kim, Daehoon ; Kim, Moon-Hyun ; Park, Je-Wook ; Yu, Hee Tae ; Kim, Tae-Hoon ; Uhm, Jae-Sun ; Joung, Boyoung ; Lee, Moon-Hyoung ; Pak, Hui-Nam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c303t-f3e2ff7450692a6d86f254691215afde761ac299d913a1253ff89a05d2c7859e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>atrial fibrillation</topic><topic>Atrial Fibrillation - diagnosis</topic><topic>Atrial Fibrillation - physiopathology</topic><topic>Atrial Fibrillation - surgery</topic><topic>Atrial Fibrillation - therapy</topic><topic>Atrial Function, Left - physiology</topic><topic>Atrial Pressure - physiology</topic><topic>Cardiac Pacing, Artificial</topic><topic>Catheter Ablation</topic><topic>Echocardiography</topic><topic>Female</topic><topic>H2FPEF score</topic><topic>Heart Failure - diagnosis</topic><topic>Heart Failure - physiopathology</topic><topic>Heart Failure - therapy</topic><topic>Heart Rate - physiology</topic><topic>Humans</topic><topic>isoproterenol</topic><topic>Isoproterenol - administration & dosage</topic><topic>left atrial pressure</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Original Research</topic><topic>pacing</topic><topic>Prospective Studies</topic><topic>Stroke Volume - physiology</topic><topic>Ventricular Function, Left - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, Jong Sung</creatorcontrib><creatorcontrib>Cho, Iksung</creatorcontrib><creatorcontrib>Kim, Daehoon</creatorcontrib><creatorcontrib>Kim, Moon-Hyun</creatorcontrib><creatorcontrib>Park, Je-Wook</creatorcontrib><creatorcontrib>Yu, Hee Tae</creatorcontrib><creatorcontrib>Kim, Tae-Hoon</creatorcontrib><creatorcontrib>Uhm, Jae-Sun</creatorcontrib><creatorcontrib>Joung, Boyoung</creatorcontrib><creatorcontrib>Lee, Moon-Hyoung</creatorcontrib><creatorcontrib>Pak, Hui-Nam</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Journal of the American Heart Association</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, Jong Sung</au><au>Cho, Iksung</au><au>Kim, Daehoon</au><au>Kim, Moon-Hyun</au><au>Park, Je-Wook</au><au>Yu, Hee Tae</au><au>Kim, Tae-Hoon</au><au>Uhm, Jae-Sun</au><au>Joung, Boyoung</au><au>Lee, Moon-Hyoung</au><au>Pak, Hui-Nam</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differentiating Left Atrial Pressure Responses in Paroxysmal and Persistent Atrial Fibrillation: Implications for Diagnosing Heart Failure With Preserved Ejection Fraction and Managing Atrial Fibrillation</atitle><jtitle>Journal of the American Heart Association</jtitle><addtitle>J Am Heart Assoc</addtitle><date>2024-09-03</date><risdate>2024</risdate><volume>13</volume><issue>17</issue><spage>e035246</spage><pages>e035246-</pages><issn>2047-9980</issn><eissn>2047-9980</eissn><abstract>Increased left atrial pressure (LAP) contributes to dyspnea and heart failure with preserved ejection fraction in patients with atrial fibrillation (AF). The purpose of this study was to investigate the differences in baseline LAP and LAP response to rapid pacing between paroxysmal and persistent AF.
This observational study prospectively enrolled 1369 participants who underwent AF catheter ablation, excluding those with reduced left ventricular ejection fraction. H
FPEF score was calculated by echocardiography and baseline characteristics. Patients underwent LAP measurements during AF, sinus rhythm, and heart rates of 90, 100, 110, and 120 beats per minute (bpm), induced by right atrial pacing and isoproterenol. The baseline LAP-peak in the persistent AF group consistently exceeded that in the paroxysmal AF (PAF) group across each H
FPEF score subgroup (all
<0.05). LAP-peak increased with pacing (19.5 to 22.5 mm Hg) but decreased with isoproterenol (20.4 to 18.4 mm Hg). Under pacing, patients with PAF exhibited a significantly lower LAP-peak (90 bpm) than those with persistent AF (17.7±8.2 versus 21.1±9.3 mm Hg,
<0.001). However, there was no difference in LAP-peak (120 bpm) between the 2 groups (22.1±8.1 versus 22.9±8.4 mm Hg,
=0.056) because the LAP-peak significantly increased with heart rate in the group with PAF.
Patients with PAF exhibited lower baseline LAP with greater increases during rapid pacing compared with individuals with persistent AF, indicating a need to revise the H
FPEF score for distinguishing PAF from persistent AF and emphasizing the importance of rate and rhythm control in PAF for symptom control.
URL: https://www.clinicaltrials.gov; Unique Identifier: NCT02138695.</abstract><cop>England</cop><pub>John Wiley and Sons Inc</pub><pmid>39189473</pmid><doi>10.1161/JAHA.124.035246</doi><orcidid>https://orcid.org/0000-0002-9736-450X</orcidid><orcidid>https://orcid.org/0000-0003-4200-3456</orcidid><orcidid>https://orcid.org/0000-0002-7268-0741</orcidid><orcidid>https://orcid.org/0000-0002-5311-4744</orcidid><orcidid>https://orcid.org/0000-0002-6835-4759</orcidid><orcidid>https://orcid.org/0000-0002-1611-8172</orcidid><orcidid>https://orcid.org/0000-0002-6608-9816</orcidid><orcidid>https://orcid.org/0000-0001-9036-7225</orcidid><orcidid>https://orcid.org/0000-0001-8594-5983</orcidid><orcidid>https://orcid.org/0000-0002-3256-3620</orcidid><orcidid>https://orcid.org/0000-0001-5927-5410</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2047-9980 |
| ispartof | Journal of the American Heart Association, 2024-09, Vol.13 (17), p.e035246 |
| issn | 2047-9980 2047-9980 |
| language | eng |
| recordid | cdi_doaj_primary_oai_doaj_org_article_677cab0225aa45ff9b06638f4b80bdd9 |
| source | Wiley Online Library Open Access; PubMed Central |
| subjects | Aged atrial fibrillation Atrial Fibrillation - diagnosis Atrial Fibrillation - physiopathology Atrial Fibrillation - surgery Atrial Fibrillation - therapy Atrial Function, Left - physiology Atrial Pressure - physiology Cardiac Pacing, Artificial Catheter Ablation Echocardiography Female H2FPEF score Heart Failure - diagnosis Heart Failure - physiopathology Heart Failure - therapy Heart Rate - physiology Humans isoproterenol Isoproterenol - administration & dosage left atrial pressure Male Middle Aged Original Research pacing Prospective Studies Stroke Volume - physiology Ventricular Function, Left - physiology |
| title | Differentiating Left Atrial Pressure Responses in Paroxysmal and Persistent Atrial Fibrillation: Implications for Diagnosing Heart Failure With Preserved Ejection Fraction and Managing Atrial Fibrillation |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T04%3A28%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Differentiating%20Left%20Atrial%20Pressure%20Responses%20in%20Paroxysmal%20and%20Persistent%20Atrial%20Fibrillation:%20Implications%20for%20Diagnosing%20Heart%20Failure%20With%20Preserved%20Ejection%20Fraction%20and%20Managing%20Atrial%20Fibrillation&rft.jtitle=Journal%20of%20the%20American%20Heart%20Association&rft.au=Park,%20Jong%20Sung&rft.date=2024-09-03&rft.volume=13&rft.issue=17&rft.spage=e035246&rft.pages=e035246-&rft.issn=2047-9980&rft.eissn=2047-9980&rft_id=info:doi/10.1161/JAHA.124.035246&rft_dat=%3Cproquest_doaj_%3E3097495421%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c303t-f3e2ff7450692a6d86f254691215afde761ac299d913a1253ff89a05d2c7859e3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=3097495421&rft_id=info:pmid/39189473&rfr_iscdi=true |