Alteration of Gut Immunity and Microbiome in Mixed Granulocytic Asthma

Growing evidence suggests that there is an essential link between the gut and lungs. Asthma is a common chronic inflammatory disease and is considered a heterogeneous disease. While it has been documented that eosinophilic asthma affects gut immunity and the microbiome, the effect of other types of...

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Bibliographic Details
Published in:Biomedicines 2022-11, Vol.10 (11), p.2946
Main Authors: Gu, Bon-Hee, Rim, Chae-Yun, Lee, Sangjin, Kim, Tae-Yong, Joo, Sang-Seok, Lee, Sang-Jin, Park, Han-Ki, Kim, Myunghoo
Format: Article
Language:English
Subjects:
Asthma
Complications and side effects
Development and progression
Disease
Dysbiosis
Fatty acids
Glycolysis
Granulocytes
gut microbiota
Health aspects
Homeostasis
Immunity
Inflammation
Inflammatory bowel disease
Inflammatory diseases
intestinal immune cells
Intestinal microflora
Laboratory animals
Leukocytes (eosinophilic)
Medical research
Metabolic diseases
microbial metabolism
Microbiomes
Microbiota
Microbiota (Symbiotic organisms)
mixed granulocytic asthma
Physiological aspects
Polyinosinic:polycytidylic acid
Relative abundance
Risk factors
Therapeutic targets
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Summary:Growing evidence suggests that there is an essential link between the gut and lungs. Asthma is a common chronic inflammatory disease and is considered a heterogeneous disease. While it has been documented that eosinophilic asthma affects gut immunity and the microbiome, the effect of other types of asthma on the gut environment has not been examined. In this study, we utilized an OVA/poly I:C-induced mixed granulocytic asthma model and found increased Tregs without significant changes in other inflammatory cells in the colon. Interestingly, an altered gut microbiome has been observed in a mixed granulocytic asthma model. We observed an increase in the relative abundance of genus and Erysipelotrichaceae family, with a concomitant decrease in the relative abundance of and . The altered gut microbiome leads to changes in the abundance of genes associated with microbial metabolism, such as glycolysis. We found that mixed granulocytic asthma mainly affects the gut microbial composition and metabolism, which may have important implications in the severity and development of asthma and gut immune homeostasis. This suggests that altered gut microbial metabolism may be a potential therapeutic target for patients with mixed granulocytic asthma.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines10112946