Alcohol Use Disorder, Neurodegeneration, Alzheimer's and Parkinson's Disease: Interplay Between Oxidative Stress, Neuroimmune Response and Excitotoxicity

Alcohol use disorder (AUD) has been associated with neurodegenerative diseases such as Alzheimer's and Parkinson's disease. Prolonged excessive alcohol intake contributes to increased production of reactive oxygen species that triggers neuroimmune response and cellular apoptosis and necros...

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Bibliographic Details
Published in:Frontiers in cellular neuroscience 2020-08, Vol.14, p.282
Main Authors: Kamal, Haziq, Tan, Geok Chin, Ibrahim, Siti Fatimah, Shaikh, Mohd Farooq, Mohamed, Isa Naina, Mohamed, Rashidi M Pakri, Hamid, Adila A, Ugusman, Azizah, Kumar, Jaya
Format: Article
Language:English
Subjects:
alcohol
Alzheimer
Apoptosis
Cell death
Cell injury
Central nervous system
DNA damage
Excitotoxicity
Glucocorticoids
Glutamic acid receptors
Immune response
Kinases
Lipid peroxidation
Lipopolysaccharides
Mitochondrial DNA
Movement disorders
Neurodegeneration
Neurodegenerative diseases
neuroimmune
neuroinflammation
Neuroscience
Oxidants
Oxidation
Oxidative stress
Parkinson's disease
Reactive oxygen species
Tumor necrosis factor-TNF
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Summary:Alcohol use disorder (AUD) has been associated with neurodegenerative diseases such as Alzheimer's and Parkinson's disease. Prolonged excessive alcohol intake contributes to increased production of reactive oxygen species that triggers neuroimmune response and cellular apoptosis and necrosis via lipid peroxidation, mitochondrial, protein or DNA damage. Long term binge alcohol consumption also upregulates glutamate receptors, glucocorticoids and reduces reuptake of glutamate in the central nervous system, resulting in glutamate excitotoxicity, and eventually mitochondrial injury and cell death. In this review, we delineate the following principles in alcohol-induced neurodegeneration: (1) alcohol-induced oxidative stress, (2) neuroimmune response toward increased oxidants and lipopolysaccharide, (3) glutamate excitotoxicity and cell injury, and (4) interplay between oxidative stress, neuroimmune response and excitotoxicity leading to neurodegeneration and (5) potential chronic alcohol intake-induced development of neurodegenerative diseases, including Alzheimer's and Parkinson's disease.
ISSN:1662-5102
1662-5102
DOI:10.3389/fncel.2020.00282