Genetic Association of rs10757278 on Chromosome 9p21 and Coronary Artery Disease in a Saudi Population

Coronary artery disease (CAD) is one of the most important leading causes of morbidity and mortality worldwide. Few studies have been carried out in the Saudi population regarding the association of rs10757278 polymorphism with CAD. This study aimed to investigate the association of the rs10757278 p...

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Bibliographic Details
Published in:International journal of general medicine 2021-01, Vol.14, p.1699-1707
Main Authors: Bogari, Neda, Dannoun, Anas, Athar, Mohammad, Elkhateeb, Osama, Porqueddu, Massimo, Allam, Reem, Alamanni, Francesco
Format: Article
Language:English
Subjects:
9p21
Age
Blood & organ donations
Cardiovascular disease
Cholesterol
coronary artery disease
Coronary vessels
Diabetes
gene polymorphism and saudi population
Genotype & phenotype
Glucose
Health risk assessment
Heart attacks
Hypertension
Lipids
Original Research
Polymorphism
Population
Risk factors
rs10757278
Variables
Variance analysis
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Summary:Coronary artery disease (CAD) is one of the most important leading causes of morbidity and mortality worldwide. Few studies have been carried out in the Saudi population regarding the association of rs10757278 polymorphism with CAD. This study aimed to investigate the association of the rs10757278 polymorphism with CAD in Saudi population. In this case-control study, we recruited 437 patients with CAD and 251 cross-matched healthy controls and performed polymorphism genotyping for rs10757278 using a polymerase chain reaction followed by a restriction fragment length polymorphism analysis. The G allele (OR-1.44; 95% CI: 1.15-1.80; p=0.001), as GG (OR-2.13; 95% CI: 1.35-3.36; p=0.0009), in the dominant (OR-1.47; 95% CI: 1.03-2.10; p=0.03) and recessive mode (OR-1.84; 95% CI: 1.26-2.70; p=0.001) of inheritance showed a high-risk association. A disease stratified risk analysis was conducted and comparisons were made using an ANOVA analysis. Diabetes showed a risk association (p=0.001). However, a regression analysis confirmed that for the CAD cases, there was an association between the GG genotype and diabetes (p=0.005). The results of this study suggest that the polymorphism rs10757278 is related to a high risk of CAD in a Saudi population.
ISSN:1178-7074
1178-7074
DOI:10.2147/IJGM.S300463