First reported case of safe and efficacious use of tocilizumab for treatment of hyperinflammatory syndrome associated with COVID‐19 in an allogeneic stem cell transplant patient

Abbreviations CMV Cytomegalovirus CRP C-Reactive Protein EBV Epstein-Barr Virus GvHD Graft-versus-host disease HSCT Haematopoietic stem cell transplant LDH Lactate dehydrogenase CASE DESCRIPTION We present the first published case demonstrating the safe and efficacious use of tocilizumab in a haemat...

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Bibliographic Details
Published in:EJHaem 2021-02, Vol.2 (1), p.143-146
Main Authors: Fordham, Nicholas, Baker, Emma, Forton, Daniel, Klammer, Matthias, Patel, Kamal, Qadir, Dara, Reyal, Yasmin, Willis, Fenella, Koh, Mickey B.C.
Format: Article
Language:English
Subjects:
Bacterial infections
C-reactive protein
Case Reports
Coronaviruses
COVID-19
Cytomegalovirus
Epstein-Barr virus
Ferritin
Graft versus host disease
Graft-versus-host reaction
Hematopoietic stem cells
L-Lactate dehydrogenase
Lactic acid
Letter
Patients
Severe acute respiratory syndrome coronavirus 2
Stem cell transplantation
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Summary:Abbreviations CMV Cytomegalovirus CRP C-Reactive Protein EBV Epstein-Barr Virus GvHD Graft-versus-host disease HSCT Haematopoietic stem cell transplant LDH Lactate dehydrogenase CASE DESCRIPTION We present the first published case demonstrating the safe and efficacious use of tocilizumab in a haematopoietic stem cell transplant (HSCT) patient with COVID-19. In this protocol, patients meeting the clinical criteria for access to tocilizumab are selected based primarily on a hyperinflammatory presentation needing at least three of the following: elevated D-dimer, rising CRP, ferritin > 1000 ng/mL, elevated LDH, in addition to confirmed SARS-CoV-2 with radiographic evidence of pneumonia and increasing oxygen requirement. [...]we illustrate the potential safety and efficacy of tocilizumab in HSCT patients.
ISSN:2688-6146
2688-6146
DOI:10.1002/jha2.132