The Role of Biopsy in the Workup of Patients with Neuroblastoma: Comparison of the Incidence of Surgical Complications and the Diagnostic Reliability of Diverse Techniques

Neuroblastoma (NB) is the most common extracranial solid tumor in childhood, accounting for approximately 15% of all cancer-related deaths in the pediatric population. The overall survival of children with high-risk disease is around 40–50% despite the aggressive treatment protocols. In accordance w...

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Bibliographic Details
Published in:Children (Basel) 2021-06, Vol.8 (6), p.500
Main Authors: Paraboschi, Irene, Bolognesi, Ester, Giannettoni, Adele, Avanzini, Stefano, Torre, Michele, Martucciello, Giuseppe
Format: Article
Language:English
Subjects:
Abdomen
Biopsy
Contraindications
Endoscopy
Hospitals
Laparoscopy
Medical diagnosis
minimally invasive laparoscopic incisional biopsy
minimally invasive thoracoscopic incisional biopsy
Neuroblastoma
open incisional biopsy
Patients
pediatric surgery
Pediatrics
Surgical outcomes
Tumors
Ultrasonic imaging
ultrasound-guided core needle biopsy
Variance analysis
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Summary:Neuroblastoma (NB) is the most common extracranial solid tumor in childhood, accounting for approximately 15% of all cancer-related deaths in the pediatric population. The overall survival of children with high-risk disease is around 40–50% despite the aggressive treatment protocols. In accordance with the most recent guidelines, a complete classification of the primary tumor, including its histopathological and molecular analysis, is necessary. In this regard, the biopsy of the primary tumor is an important diagnostic procedure adopted not only to confirm the diagnosis but also for staging and risk stratification of the disease. In this study, the authors describe their unicentric experience with four different approaches adopted for sampling NB tumors: (i) the open incisional biopsy; (ii) the minimally invasive thoracoscopic/laparoscopic incisional biopsy; (iii) the ultrasound-guided core needle biopsy; (iv) the laparoscopic-assisted core needle biopsy. The benefits of each technique are analyzed along with their contraindications.
ISSN:2227-9067
2227-9067
DOI:10.3390/children8060500