Probiotics for Alleviating Alcoholic Liver Injury

Many animal experiments and clinical trials showed that probiotics are effective for the treatment of alcoholic liver disease. Alcohol disrupts the composition of intestinal flora; probiotics modulate the gut microbiota and reverse alcohol-associated intestinal barrier dysfunction by decreasing inte...

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Bibliographic Details
Published in:Gastroenterology research and practice 2019-01, Vol.2019 (2019), p.1-8
Main Authors: Wang, Yuhua, You, Jiaqi Wen, You, Ying, Hu, Shumeng, Liu, Yanlong, Gu, Zelin, Li, Wancong
Format: Article
Language:English
Subjects:
Alcohol use
Alcoholism
Animal experimentation
Bacteria
Care and treatment
Cytokines
Fatty acids
Gastroenterology
Hepatitis
Hepatology
Immune response
Immune system
Kinases
Lipids
Liver
Liver cirrhosis
Liver diseases
Metabolism
Microbiota
Microbiota (Symbiotic organisms)
Oxidation
Oxidative stress
Permeability
Phosphorylation
Physiology
Probiotics
Proteins
Review
Studies
Substance abuse
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Summary:Many animal experiments and clinical trials showed that probiotics are effective for the treatment of alcoholic liver disease. Alcohol disrupts the composition of intestinal flora; probiotics modulate the gut microbiota and reverse alcohol-associated intestinal barrier dysfunction by decreasing intestinal mucosal permeability and preventing intestinal bacteria from translocating. Probiotics enhance immune responses and reduce the levels of alcohol-induced inflammatory cytokines and reactive oxygen species (ROS) production in the liver and intestine. Probiotics also increase fatty acid β-oxidation and reduce lipogenesis, combating alcohol-induced hepatic steatosis. In this review, we summarize the current knowledge regarding the mechanism of action of probiotics for reducing the effects of alcoholic liver disease.
ISSN:1687-6121
1687-630X
DOI:10.1155/2019/9097276