A Fully Automated Synthesis of 14-( R,S )-[ 18 F]fluoro-6-thia-heptadecanoic Acid ([ 18 F]FTHA) on the Elixys Radiosynthesizer

14-( )-[ F]fluoro-6-thia-heptadecanoic acid ([ F]FTHA) is a radiocompound for imaging the fatty acid circulation by positron emission tomography. A revived interest in imaging of lipid metabolism led us to a constant tracer production over three years, initially using a conventional vessel-based syn...

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Bibliographic Details
Published in:Pharmaceuticals (Basel, Switzerland) Switzerland), 2024-02, Vol.17 (3), p.318
Main Authors: Ustsinau, Usevalad, Nics, Lukas, Hacker, Marcus, Philippe, Cecile
Format: Article
Language:English
Subjects:
[18F]FTHA
Automation
Body fat
fatty acid metabolism
Fatty acids
Fluorides
fluorine-18
Glucose
Good Manufacturing Practice
Metabolism
Metabolites
Oxidation
Quality control
radiosynthesis
Reagents
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Summary:14-( )-[ F]fluoro-6-thia-heptadecanoic acid ([ F]FTHA) is a radiocompound for imaging the fatty acid circulation by positron emission tomography. A revived interest in imaging of lipid metabolism led us to a constant tracer production over three years, initially using a conventional vessel-based synthesizer and later transitioning to the cassette-based Elixys synthesizer. On the Elixys module, the radiochemical yield of [ F]FTHA could be increased by more than two times, reaching 13.01 ± 5.63% at the end of the synthesis, while maintaining necessary quality control results.
ISSN:1424-8247
1424-8247
DOI:10.3390/ph17030318