Epigallocatechin-3-Gallate (EGCG): New Therapeutic Perspectives for Neuroprotection, Aging, and Neuroinflammation for the Modern Age

Alzheimer's and Parkinson's diseases are the two most common forms of neurodegenerative diseases. The exact etiology of these disorders is not well known; however, environmental, molecular, and genetic influences play a major role in the pathogenesis of these diseases. Using Alzheimer'...

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Bibliographic Details
Published in:Biomolecules (Basel, Switzerland) Switzerland), 2022-02, Vol.12 (3), p.371
Main Authors: Payne, Ashley, Nahashon, Samuel, Taka, Equar, Adinew, Getinet M, Soliman, Karam F A
Format: Article
Language:English
Subjects:
Aging
aging and epigallocatechin-3-gallate (EGCG)
Alzheimer Disease - metabolism
Alzheimer's disease
Alzheimer’s disease (AD)
Amyloid beta-Peptides
Antioxidants
Catechin - analogs & derivatives
Epigallocatechin gallate
Etiology
Functional foods & nutraceuticals
Green tea
Humans
Inflammation
microglia
Mitochondria
Neurodegeneration
Neurodegenerative diseases
Neuroinflammatory Diseases
Neuroprotection
Neuroprotective Agents - chemistry
Neuroprotective Agents - pharmacology
Neuroprotective Agents - therapeutic use
Oxidative stress
Parkinson's disease
Pathology
Phytochemicals
Reactive oxygen species
Review
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Summary:Alzheimer's and Parkinson's diseases are the two most common forms of neurodegenerative diseases. The exact etiology of these disorders is not well known; however, environmental, molecular, and genetic influences play a major role in the pathogenesis of these diseases. Using Alzheimer's disease (AD) as the archetype, the pathological findings include the aggregation of Amyloid Beta (Aβ) peptides, mitochondrial dysfunction, synaptic degradation caused by inflammation, elevated reactive oxygen species (ROS), and cerebrovascular dysregulation. This review highlights the neuroinflammatory and neuroprotective role of epigallocatechin-3-gallate (EGCG): the medicinal component of green tea, a known nutraceutical that has shown promise in modulating AD progression due to its antioxidant, anti-inflammatory, and anti-aging abilities. This report also re-examines the current literature and provides innovative approaches for EGCG to be used as a preventive measure to alleviate AD and other neurodegenerative disorders.
ISSN:2218-273X
2218-273X
DOI:10.3390/biom12030371