It is the time for quorum sensing inhibition as alternative strategy of antimicrobial therapy

Multiple drug resistance poses a significant threat to public health worldwide, with a substantial increase in morbidity and mortality rates. Consequently, searching for novel strategies to control microbial pathogenicity is necessary. With the aid of auto-inducers (AIs), quorum sensing (QS) regulat...

Full description

Saved in:
Bibliographic Details
Published in:Cell communication and signaling 2023-06, Vol.21 (1), p.133-133, Article 133
Main Authors: Naga, Nourhan G, El-Badan, Dalia E, Ghanem, Khaled M, Shaaban, Mona I
Format: Article
Language:English
Subjects:
Anti-Infective Agents
Antibiotics
Antimicrobial agents
Autoinducers
Bacteria
Biofilms
Biosensors
Cell Communication
Cell Cycle
Cell signaling
Chromatography
Drug dosages
Drug resistance
E coli
Enzymes
Gene expression
Gram-negative bacteria
Gram-positive bacteria
Humans
Infectious diseases
Inoculum
Kinases
Methods
Microorganisms
Morbidity
Multidrug resistance
Multiple drug resistance
Pathogenicity
Peptides
Pharmaceutical industry
Public health
Quorum Sensing
Review
Staphylococcus infections
Stationary phase
Virulence
Virulence factors
Water treatment
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Multiple drug resistance poses a significant threat to public health worldwide, with a substantial increase in morbidity and mortality rates. Consequently, searching for novel strategies to control microbial pathogenicity is necessary. With the aid of auto-inducers (AIs), quorum sensing (QS) regulates bacterial virulence factors through cell-to-cell signaling networks. AIs are small signaling molecules produced during the stationary phase. When bacterial cultures reach a certain level of growth, these molecules regulate the expression of the bound genes by acting as mirrors that reflect the inoculum density.Gram-positive bacteria use the peptide derivatives of these signaling molecules, whereas Gram-negative bacteria use the fatty acid derivatives, and the majority of bacteria can use both types to modulate the expression of the target gene. Numerous natural and synthetic QS inhibitors (QSIs) have been developed to reduce microbial pathogenesis. Applications of QSI are vital to human health, as well as fisheries and aquaculture, agriculture, and water treatment. Video Abstract.
ISSN:1478-811X
1478-811X
DOI:10.1186/s12964-023-01154-9