Tirucallane Triterpenoids from the Stems and Stem Bark of Cornus walteri that Control Adipocyte and Osteoblast Differentiations

Wanger (Cornaceae) has been broadly used in traditional East Asian medicine for the treatment of various disorders, including skin inflammation and diarrhea. As part of our efforts to identify structurally and/or biologically new compounds from Korean medicinal plants, we have explored potentially n...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2018-10, Vol.23 (11), p.2732
Main Authors: Lee, Seoung Rak, Choi, Eunyong, Jeon, Se Hun, Zhi, Xue Yan, Yu, Jae Sik, Kim, Seon-Hee, Lee, Jeongmi, Park, Ki-Moon, Kim, Ki Hyun
Format: Article
Language:English
Subjects:
Adipocytes
Adipogenesis
Bark
Biomedical materials
Bone marrow
Cell differentiation
Chalybion walteri
Communication
Computer applications
Cornus
Cornus walteri
cornusalterins N-P
Cytotoxicity
Diarrhea
Differentiation
Herbal medicine
Investigations
Lipids
Medicinal plants
mesenchymal stem cell
Mesenchyme
NMR
Nuclear magnetic resonance
Osteoblastogenesis
Osteoblasts
Phytochemicals
Stem cells
triterpenoid
Triterpenoids
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Summary:Wanger (Cornaceae) has been broadly used in traditional East Asian medicine for the treatment of various disorders, including skin inflammation and diarrhea. As part of our efforts to identify structurally and/or biologically new compounds from Korean medicinal plants, we have explored potentially new bioactive constituents from . In the present study, seven triterpenoids ( ⁻ ) were isolated from stems and stem bark. Compounds ⁻ were new tirucallane triterpenoids (cornusalterins N-P) and compounds ⁻ were isolated for the first time from . The structures of the new compounds were determined based on 1D and 2D NMR spectroscopic data interpretations and HR-ESIMS, as well as a computational method coupled with a statistical procedure (DP4+). The regulatory effects of the isolated triterpenoids ( ⁻ ) on mesenchymal stem cell (MSC) differentiation to adipocytes and osteoblasts were examined in the C3H10T1/2 cell line. Although these compounds had little effect on MSC differentiation to osteoblasts, lipid droplet formation in adipocyte-differentiated MSCs decreased in the presence of the seven triterpenoids. Compounds and each had a relatively distinct correlation between dose and efficacy, showing adipogenesis suppression at higher concentrations. Our findings demonstrate that the active compounds and can exert beneficial effects in regulation of adipocyte differentiation.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules23112732