ATP Synthase: Structure, Function and Inhibition

Oxidative phosphorylation is carried out by five complexes, which are the sites for electron transport and ATP synthesis. Among those, Complex V (also known as the F ATP Synthase or ATPase) is responsible for the generation of ATP through phosphorylation of ADP by using electrochemical energy genera...

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Bibliographic Details
Published in:Biomolecular concepts 2019-03, Vol.10 (1), p.1-10
Main Authors: Neupane, Prashant, Bhuju, Sudina, Thapa, Nita, Bhattarai, Hitesh Kumar
Format: Article
Language:English
Subjects:
Adenosine triphosphatase
ATP
ATP Synthase
ATP synthase Inhibition
Electron transport
Electron Transport Chain
Mitochondria
Oxidative phosphorylation
Phosphorylation
Proton motive force
Rotational Catalysis
Structure-function relationships
Subunit structure
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Summary:Oxidative phosphorylation is carried out by five complexes, which are the sites for electron transport and ATP synthesis. Among those, Complex V (also known as the F ATP Synthase or ATPase) is responsible for the generation of ATP through phosphorylation of ADP by using electrochemical energy generated by proton gradient across the inner membrane of mitochondria. A multi subunit structure that works like a pump functions along the proton gradient across the membranes which not only results in ATP synthesis and breakdown, but also facilitates electron transport. Since ATP is the major energy currency in all living cells, its synthesis and function have widely been studied over the last few decades uncovering several aspects of ATP synthase. This review intends to summarize the structure, function and inhibition of the ATP synthase.
ISSN:1868-5021
1868-503X
DOI:10.1515/bmc-2019-0001