Regulation of Resistance in Vancomycin-Resistant Enterococci: The VanRS Two-Component System

Vancomycin-resistant enterococci (VRE) are a serious threat to human health, with few treatment options being available. New therapeutics are urgently needed to relieve the health and economic burdens presented by VRE. A potential target for new therapeutics is the VanRS two-component system, which...

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Bibliographic Details
Published in:Microorganisms (Basel) 2021-09, Vol.9 (10), p.2026
Main Authors: Guffey, Alexandra A, Loll, Patrick J
Format: Article
Language:English
Subjects:
Antibiotic resistance
Antibiotics
Gene expression
Genes
Gram-positive bacteria
Histidine
Histidine kinase
Infections
Kinases
Penicillin
Regulation
Review
two-component system
Vancomycin
Vans
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Summary:Vancomycin-resistant enterococci (VRE) are a serious threat to human health, with few treatment options being available. New therapeutics are urgently needed to relieve the health and economic burdens presented by VRE. A potential target for new therapeutics is the VanRS two-component system, which regulates the expression of vancomycin resistance in VRE. VanS is a sensor histidine kinase that detects vancomycin and in turn activates VanR; VanR is a response regulator that, when activated, directs expression of vancomycin-resistance genes. This review of VanRS examines how the expression of vancomycin resistance is regulated, and provides an update on one of the field's most pressing questions: How does VanS sense vancomycin?
ISSN:2076-2607
2076-2607
DOI:10.3390/microorganisms9102026