Sildenafil-Mediated Neuroprotection from Adult to Neonatal Brain Injury: Evidence, Mechanisms, and Future Translation

Cerebral stroke, traumatic brain injury, and hypoxic ischemic encephalopathy are among the most frequently occurring brain injuries. A complex pathogenesis, characterized by a synergistic interaction between alterations of the cerebrovascular system, cell death, and inflammation, is at the basis of...

Full description

Saved in:
Bibliographic Details
Published in:Cells (Basel, Switzerland) Switzerland), 2021-10, Vol.10 (10), p.2766
Main Authors: Zinni, Manuela, Pansiot, Julien, Léger, Pierre-Louis, El Kamouh, Marina, Baud, Olivier
Format: Article
Language:English
Subjects:
Adult
Adults
Angina pectoris
Angiogenesis
Apoptosis
Blood-brain barrier
Brain damage
Brain Injuries - drug therapy
brain injury
Cell death
Cellular Biology
Cerebrovascular system
Drug dosages
Encephalopathy
Enzymes
FDA approval
Flow velocity
Humans
Hypoxia
Infant, Newborn
Ischemia
Life Sciences
Neonates
Neurodevelopmental disorders
Neuroprotection
Neuroprotection - drug effects
Nitric oxide
Nitric Oxide - metabolism
Pathogenesis
Phosphodiesterase
Pulmonary hypertension
Review
Rodents
Sex Characteristics
Signal transduction
Sildenafil
Sildenafil Citrate - pharmacology
Sildenafil Citrate - therapeutic use
Translational Research, Biomedical
Traumatic brain injury
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cerebral stroke, traumatic brain injury, and hypoxic ischemic encephalopathy are among the most frequently occurring brain injuries. A complex pathogenesis, characterized by a synergistic interaction between alterations of the cerebrovascular system, cell death, and inflammation, is at the basis of the brain damage that leads to behavioral and neurodevelopmental disabilities in affected subjects. Sildenafil is a selective inhibitor of the enzyme phosphodiesterase 5 (PDE5) that is able to cross the blood-brain barrier. Preclinical data suggest that sildenafil may be a good candidate for the prevention or repair of brain injury in both adults and neonates. The aim of this review is to summarize the evidence supporting the neuroprotective action of sildenafil and discuss the possible benefits of the association of sildenafil with current therapeutic strategies.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells10102766