The Therapeutic Potential of the Endocannabinoid System in Age-Related Diseases

The endocannabinoid system (ECS) dynamically regulates many aspects of mammalian physiology. ECS has gained substantial interest since growing evidence suggests that it also plays a major role in several pathophysiological conditions due to its ability to modulate various underlying mechanisms. Furt...

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Bibliographic Details
Published in:Biomedicines 2022-10, Vol.10 (10), p.2492
Main Authors: Tudorancea, Ivona Maria, Ciorpac, Mitică, Stanciu, Gabriela Dumitrița, Caratașu, Cătălin, Săcărescu, Alina, Ignat, Bogdan, Burlui, Alexandra, Rezuș, Elena, Creangă, Ioana, Alexa-Stratulat, Teodora, Tudorancea, Ionuț, Tamba, Bogdan Ionel
Format: Article
Language:English
Subjects:
age-related diseases
Aging
Analgesics
Cannabidiol
cannabinoid receptors
Cannabinoids
Chronic illnesses
Cytokines
Endocannabinoid system
Enzymes
Health aspects
Immune system
Immunomodulation
Inflammation
Medical prognosis
Mortality
Multiple sclerosis
Nervous system
Parkinson's disease
Physiology
Population
Review
Tumor necrosis factor-TNF
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Summary:The endocannabinoid system (ECS) dynamically regulates many aspects of mammalian physiology. ECS has gained substantial interest since growing evidence suggests that it also plays a major role in several pathophysiological conditions due to its ability to modulate various underlying mechanisms. Furthermore, cannabinoids, as components of the cannabinoid system (CS), have proven beneficial effects such as anti-inflammatory, immunomodulatory, neuromodulatory, antioxidative, and cardioprotective effects. In this comprehensive review, we aimed to describe the complex interaction between CS and most common age-related diseases such as neuro-degenerative, oncological, skeletal, and cardiovascular disorders, together with the potential of various cannabinoids to ameliorate the progression of these disorders. Since chronic inflammation is postulated as the pillar of all the above-mentioned medical conditions, we also discuss in this paper the potential of CS to ameliorate aging-associated immune system dysregulation.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines10102492