Loading…

Circulating microRNAs improve bacterial infection diagnosis and overall survival prediction in acute decompensation of liver cirrhosis

Bacterial infections are the most frequent precipitating event in patients with acute decompensation of cirrhosis (AD) and are associated with high mortality. Early diagnosis is challenging due to cirrhosis-related systemic inflammation. Here we investigated the potential of circulating microRNAs to...

Full description

Saved in:
Bibliographic Details
Published in:iScience 2023-08, Vol.26 (8), p.107427-107427, Article 107427
Main Authors: Chouik, Yasmina, Lebossé, Fanny, Plissonnier, Marie-Laure, Lega, Jean-Christophe, Pradat, Pierre, Antonini, Teresa, Subic, Miroslava, Hartig-Lavie, Kerstin, Erard, Domitille, Villeret, François, Guichon, Céline, Payancé, Audrey, Radenne, Sylvie, Rautou, Pierre-Emmanuel, Zoulim, Fabien, Levrero, Massimo
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c556t-7559de973f12f14369b956a82cb8d2fe1ae6a99541047776b304844cf625daef3
cites cdi_FETCH-LOGICAL-c556t-7559de973f12f14369b956a82cb8d2fe1ae6a99541047776b304844cf625daef3
container_end_page 107427
container_issue 8
container_start_page 107427
container_title iScience
container_volume 26
creator Chouik, Yasmina
Lebossé, Fanny
Plissonnier, Marie-Laure
Lega, Jean-Christophe
Pradat, Pierre
Antonini, Teresa
Subic, Miroslava
Hartig-Lavie, Kerstin
Erard, Domitille
Villeret, François
Guichon, Céline
Payancé, Audrey
Radenne, Sylvie
Rautou, Pierre-Emmanuel
Zoulim, Fabien
Levrero, Massimo
description Bacterial infections are the most frequent precipitating event in patients with acute decompensation of cirrhosis (AD) and are associated with high mortality. Early diagnosis is challenging due to cirrhosis-related systemic inflammation. Here we investigated the potential of circulating microRNAs to diagnose bacterial infections and predict survival in cirrhotic patients with AD. High throughput profiling of circulating microRNAs was performed using the Nanostring technology in 57 AD patients and 24 patients with compensated cirrhosis (CC). Circulating miRs profiling showed that: (a) miRs differentially detected in AD vs. CC were mostly down-regulated; (b) a composite score including absolute neutrophil count, C reactive protein and miR-362-3p could diagnose bacterial infection with an excellent performance (AUC of 0.825 [95% CI = 0.671–0.980; p 
doi_str_mv 10.1016/j.isci.2023.107427
format article
fullrecord <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_681a2a68d7d84002818a7c1dd208e296</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S2589004223015043</els_id><doaj_id>oai_doaj_org_article_681a2a68d7d84002818a7c1dd208e296</doaj_id><sourcerecordid>2850719309</sourcerecordid><originalsourceid>FETCH-LOGICAL-c556t-7559de973f12f14369b956a82cb8d2fe1ae6a99541047776b304844cf625daef3</originalsourceid><addsrcrecordid>eNp9ksFq3DAQhk1paUKaF-ih6NgedivJliVBoSxLmwSWFkp7FlppvKvFtraSbcgL9Lk7Gych6aFgsBl_88me-YviLaNLRln98bAM2YUlp7zEgqy4fFGcc6H0gtKKv3zyfFZc5nyglHK8Kl2_Ls5KKaRgUp8Xf9YhubG1Q-h3pAsuxR_fVpmE7pjiBGRr3QAp2JaEvgE3hNgTH-yujzlkYntPkEq2bUke0xQmBI8JfJjJ0BPrxgGIBxe7I_TZ3tVjQ9qAfcSFlPYn1ZviVWPbDJf394vi19cvP9fXi833q5v1arNwQtTDQgqhPWhZNow3rCprvdWitoq7rfK8AWahtlqLitFKSllvS1qpqnJNzYW30JQXxc3s9dEezDGFzqZbE20wd4WYdsamIbgWTK2Y5bZWXnpV4eQUU1Y65j2nCriu0fV5dh3HbQfeQT_gJJ5Jn7_pw97s4mTw45jQZYWGD7Nh_0_f9WpjTjUEFVeinBiy7-9PS_H3CHkwHQYA2tb2EMdsEKOS6ZJqRPmM4jZzTtA8uhk1p_CYgzmFx5zCY-bwYNO7p3_z2PIQFQQ-zQDgfqYAyaACeofbTpgMHGD4n_8vIi7XdQ</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2850719309</pqid></control><display><type>article</type><title>Circulating microRNAs improve bacterial infection diagnosis and overall survival prediction in acute decompensation of liver cirrhosis</title><source>PMC (PubMed Central)</source><source>ScienceDirect (Elsevier)</source><creator>Chouik, Yasmina ; Lebossé, Fanny ; Plissonnier, Marie-Laure ; Lega, Jean-Christophe ; Pradat, Pierre ; Antonini, Teresa ; Subic, Miroslava ; Hartig-Lavie, Kerstin ; Erard, Domitille ; Villeret, François ; Guichon, Céline ; Payancé, Audrey ; Radenne, Sylvie ; Rautou, Pierre-Emmanuel ; Zoulim, Fabien ; Levrero, Massimo</creator><creatorcontrib>Chouik, Yasmina ; Lebossé, Fanny ; Plissonnier, Marie-Laure ; Lega, Jean-Christophe ; Pradat, Pierre ; Antonini, Teresa ; Subic, Miroslava ; Hartig-Lavie, Kerstin ; Erard, Domitille ; Villeret, François ; Guichon, Céline ; Payancé, Audrey ; Radenne, Sylvie ; Rautou, Pierre-Emmanuel ; Zoulim, Fabien ; Levrero, Massimo</creatorcontrib><description>Bacterial infections are the most frequent precipitating event in patients with acute decompensation of cirrhosis (AD) and are associated with high mortality. Early diagnosis is challenging due to cirrhosis-related systemic inflammation. Here we investigated the potential of circulating microRNAs to diagnose bacterial infections and predict survival in cirrhotic patients with AD. High throughput profiling of circulating microRNAs was performed using the Nanostring technology in 57 AD patients and 24 patients with compensated cirrhosis (CC). Circulating miRs profiling showed that: (a) miRs differentially detected in AD vs. CC were mostly down-regulated; (b) a composite score including absolute neutrophil count, C reactive protein and miR-362-3p could diagnose bacterial infection with an excellent performance (AUC of 0.825 [95% CI = 0.671–0.980; p &lt; 0.001]); (c) a composite score including miR-382-5p, miR-592 and MELD-Na improved 6-month survival prediction. Circulating miRs are strongly dysregulated in patients with AD and may help to improve bacterial infection diagnosis and survival prediction. [Display omitted] •Plasma miRNAs are down-regulated in AD of cirrhosis•miR-362-3p improves bacterial infection diagnosis in AD patients•miR-382-5p and miR-592 refine MELD-Na survival prediction in AD patients Bacteriology; Cell biology;</description><identifier>ISSN: 2589-0042</identifier><identifier>EISSN: 2589-0042</identifier><identifier>DOI: 10.1016/j.isci.2023.107427</identifier><identifier>PMID: 37575179</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Bacteriology ; Biochemistry, Molecular Biology ; Cell biology ; Genomics ; Human health and pathology ; Hépatology and Gastroenterology ; Infectious diseases ; Life Sciences</subject><ispartof>iScience, 2023-08, Vol.26 (8), p.107427-107427, Article 107427</ispartof><rights>2023 The Authors</rights><rights>2023 The Authors.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>2023 The Authors 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c556t-7559de973f12f14369b956a82cb8d2fe1ae6a99541047776b304844cf625daef3</citedby><cites>FETCH-LOGICAL-c556t-7559de973f12f14369b956a82cb8d2fe1ae6a99541047776b304844cf625daef3</cites><orcidid>0000-0001-7548-3703 ; 0000-0002-9327-4590 ; 0000-0002-3411-1580 ; 0000-0002-2245-0083 ; 0000-0002-4978-0875 ; 0000-0001-7789-7264 ; 0000-0002-9398-2968 ; 0000-0003-4879-4586</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10415934/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S2589004223015043$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,3549,27924,27925,45780,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37575179$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-04182853$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Chouik, Yasmina</creatorcontrib><creatorcontrib>Lebossé, Fanny</creatorcontrib><creatorcontrib>Plissonnier, Marie-Laure</creatorcontrib><creatorcontrib>Lega, Jean-Christophe</creatorcontrib><creatorcontrib>Pradat, Pierre</creatorcontrib><creatorcontrib>Antonini, Teresa</creatorcontrib><creatorcontrib>Subic, Miroslava</creatorcontrib><creatorcontrib>Hartig-Lavie, Kerstin</creatorcontrib><creatorcontrib>Erard, Domitille</creatorcontrib><creatorcontrib>Villeret, François</creatorcontrib><creatorcontrib>Guichon, Céline</creatorcontrib><creatorcontrib>Payancé, Audrey</creatorcontrib><creatorcontrib>Radenne, Sylvie</creatorcontrib><creatorcontrib>Rautou, Pierre-Emmanuel</creatorcontrib><creatorcontrib>Zoulim, Fabien</creatorcontrib><creatorcontrib>Levrero, Massimo</creatorcontrib><title>Circulating microRNAs improve bacterial infection diagnosis and overall survival prediction in acute decompensation of liver cirrhosis</title><title>iScience</title><addtitle>iScience</addtitle><description>Bacterial infections are the most frequent precipitating event in patients with acute decompensation of cirrhosis (AD) and are associated with high mortality. Early diagnosis is challenging due to cirrhosis-related systemic inflammation. Here we investigated the potential of circulating microRNAs to diagnose bacterial infections and predict survival in cirrhotic patients with AD. High throughput profiling of circulating microRNAs was performed using the Nanostring technology in 57 AD patients and 24 patients with compensated cirrhosis (CC). Circulating miRs profiling showed that: (a) miRs differentially detected in AD vs. CC were mostly down-regulated; (b) a composite score including absolute neutrophil count, C reactive protein and miR-362-3p could diagnose bacterial infection with an excellent performance (AUC of 0.825 [95% CI = 0.671–0.980; p &lt; 0.001]); (c) a composite score including miR-382-5p, miR-592 and MELD-Na improved 6-month survival prediction. Circulating miRs are strongly dysregulated in patients with AD and may help to improve bacterial infection diagnosis and survival prediction. [Display omitted] •Plasma miRNAs are down-regulated in AD of cirrhosis•miR-362-3p improves bacterial infection diagnosis in AD patients•miR-382-5p and miR-592 refine MELD-Na survival prediction in AD patients Bacteriology; Cell biology;</description><subject>Bacteriology</subject><subject>Biochemistry, Molecular Biology</subject><subject>Cell biology</subject><subject>Genomics</subject><subject>Human health and pathology</subject><subject>Hépatology and Gastroenterology</subject><subject>Infectious diseases</subject><subject>Life Sciences</subject><issn>2589-0042</issn><issn>2589-0042</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNp9ksFq3DAQhk1paUKaF-ih6NgedivJliVBoSxLmwSWFkp7FlppvKvFtraSbcgL9Lk7Gych6aFgsBl_88me-YviLaNLRln98bAM2YUlp7zEgqy4fFGcc6H0gtKKv3zyfFZc5nyglHK8Kl2_Ls5KKaRgUp8Xf9YhubG1Q-h3pAsuxR_fVpmE7pjiBGRr3QAp2JaEvgE3hNgTH-yujzlkYntPkEq2bUke0xQmBI8JfJjJ0BPrxgGIBxe7I_TZ3tVjQ9qAfcSFlPYn1ZviVWPbDJf394vi19cvP9fXi833q5v1arNwQtTDQgqhPWhZNow3rCprvdWitoq7rfK8AWahtlqLitFKSllvS1qpqnJNzYW30JQXxc3s9dEezDGFzqZbE20wd4WYdsamIbgWTK2Y5bZWXnpV4eQUU1Y65j2nCriu0fV5dh3HbQfeQT_gJJ5Jn7_pw97s4mTw45jQZYWGD7Nh_0_f9WpjTjUEFVeinBiy7-9PS_H3CHkwHQYA2tb2EMdsEKOS6ZJqRPmM4jZzTtA8uhk1p_CYgzmFx5zCY-bwYNO7p3_z2PIQFQQ-zQDgfqYAyaACeofbTpgMHGD4n_8vIi7XdQ</recordid><startdate>20230818</startdate><enddate>20230818</enddate><creator>Chouik, Yasmina</creator><creator>Lebossé, Fanny</creator><creator>Plissonnier, Marie-Laure</creator><creator>Lega, Jean-Christophe</creator><creator>Pradat, Pierre</creator><creator>Antonini, Teresa</creator><creator>Subic, Miroslava</creator><creator>Hartig-Lavie, Kerstin</creator><creator>Erard, Domitille</creator><creator>Villeret, François</creator><creator>Guichon, Céline</creator><creator>Payancé, Audrey</creator><creator>Radenne, Sylvie</creator><creator>Rautou, Pierre-Emmanuel</creator><creator>Zoulim, Fabien</creator><creator>Levrero, Massimo</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-7548-3703</orcidid><orcidid>https://orcid.org/0000-0002-9327-4590</orcidid><orcidid>https://orcid.org/0000-0002-3411-1580</orcidid><orcidid>https://orcid.org/0000-0002-2245-0083</orcidid><orcidid>https://orcid.org/0000-0002-4978-0875</orcidid><orcidid>https://orcid.org/0000-0001-7789-7264</orcidid><orcidid>https://orcid.org/0000-0002-9398-2968</orcidid><orcidid>https://orcid.org/0000-0003-4879-4586</orcidid></search><sort><creationdate>20230818</creationdate><title>Circulating microRNAs improve bacterial infection diagnosis and overall survival prediction in acute decompensation of liver cirrhosis</title><author>Chouik, Yasmina ; Lebossé, Fanny ; Plissonnier, Marie-Laure ; Lega, Jean-Christophe ; Pradat, Pierre ; Antonini, Teresa ; Subic, Miroslava ; Hartig-Lavie, Kerstin ; Erard, Domitille ; Villeret, François ; Guichon, Céline ; Payancé, Audrey ; Radenne, Sylvie ; Rautou, Pierre-Emmanuel ; Zoulim, Fabien ; Levrero, Massimo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c556t-7559de973f12f14369b956a82cb8d2fe1ae6a99541047776b304844cf625daef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Bacteriology</topic><topic>Biochemistry, Molecular Biology</topic><topic>Cell biology</topic><topic>Genomics</topic><topic>Human health and pathology</topic><topic>Hépatology and Gastroenterology</topic><topic>Infectious diseases</topic><topic>Life Sciences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chouik, Yasmina</creatorcontrib><creatorcontrib>Lebossé, Fanny</creatorcontrib><creatorcontrib>Plissonnier, Marie-Laure</creatorcontrib><creatorcontrib>Lega, Jean-Christophe</creatorcontrib><creatorcontrib>Pradat, Pierre</creatorcontrib><creatorcontrib>Antonini, Teresa</creatorcontrib><creatorcontrib>Subic, Miroslava</creatorcontrib><creatorcontrib>Hartig-Lavie, Kerstin</creatorcontrib><creatorcontrib>Erard, Domitille</creatorcontrib><creatorcontrib>Villeret, François</creatorcontrib><creatorcontrib>Guichon, Céline</creatorcontrib><creatorcontrib>Payancé, Audrey</creatorcontrib><creatorcontrib>Radenne, Sylvie</creatorcontrib><creatorcontrib>Rautou, Pierre-Emmanuel</creatorcontrib><creatorcontrib>Zoulim, Fabien</creatorcontrib><creatorcontrib>Levrero, Massimo</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>iScience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chouik, Yasmina</au><au>Lebossé, Fanny</au><au>Plissonnier, Marie-Laure</au><au>Lega, Jean-Christophe</au><au>Pradat, Pierre</au><au>Antonini, Teresa</au><au>Subic, Miroslava</au><au>Hartig-Lavie, Kerstin</au><au>Erard, Domitille</au><au>Villeret, François</au><au>Guichon, Céline</au><au>Payancé, Audrey</au><au>Radenne, Sylvie</au><au>Rautou, Pierre-Emmanuel</au><au>Zoulim, Fabien</au><au>Levrero, Massimo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating microRNAs improve bacterial infection diagnosis and overall survival prediction in acute decompensation of liver cirrhosis</atitle><jtitle>iScience</jtitle><addtitle>iScience</addtitle><date>2023-08-18</date><risdate>2023</risdate><volume>26</volume><issue>8</issue><spage>107427</spage><epage>107427</epage><pages>107427-107427</pages><artnum>107427</artnum><issn>2589-0042</issn><eissn>2589-0042</eissn><abstract>Bacterial infections are the most frequent precipitating event in patients with acute decompensation of cirrhosis (AD) and are associated with high mortality. Early diagnosis is challenging due to cirrhosis-related systemic inflammation. Here we investigated the potential of circulating microRNAs to diagnose bacterial infections and predict survival in cirrhotic patients with AD. High throughput profiling of circulating microRNAs was performed using the Nanostring technology in 57 AD patients and 24 patients with compensated cirrhosis (CC). Circulating miRs profiling showed that: (a) miRs differentially detected in AD vs. CC were mostly down-regulated; (b) a composite score including absolute neutrophil count, C reactive protein and miR-362-3p could diagnose bacterial infection with an excellent performance (AUC of 0.825 [95% CI = 0.671–0.980; p &lt; 0.001]); (c) a composite score including miR-382-5p, miR-592 and MELD-Na improved 6-month survival prediction. Circulating miRs are strongly dysregulated in patients with AD and may help to improve bacterial infection diagnosis and survival prediction. [Display omitted] •Plasma miRNAs are down-regulated in AD of cirrhosis•miR-362-3p improves bacterial infection diagnosis in AD patients•miR-382-5p and miR-592 refine MELD-Na survival prediction in AD patients Bacteriology; Cell biology;</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>37575179</pmid><doi>10.1016/j.isci.2023.107427</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-7548-3703</orcidid><orcidid>https://orcid.org/0000-0002-9327-4590</orcidid><orcidid>https://orcid.org/0000-0002-3411-1580</orcidid><orcidid>https://orcid.org/0000-0002-2245-0083</orcidid><orcidid>https://orcid.org/0000-0002-4978-0875</orcidid><orcidid>https://orcid.org/0000-0001-7789-7264</orcidid><orcidid>https://orcid.org/0000-0002-9398-2968</orcidid><orcidid>https://orcid.org/0000-0003-4879-4586</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2589-0042
ispartof iScience, 2023-08, Vol.26 (8), p.107427-107427, Article 107427
issn 2589-0042
2589-0042
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_681a2a68d7d84002818a7c1dd208e296
source PMC (PubMed Central); ScienceDirect (Elsevier)
subjects Bacteriology
Biochemistry, Molecular Biology
Cell biology
Genomics
Human health and pathology
Hépatology and Gastroenterology
Infectious diseases
Life Sciences
title Circulating microRNAs improve bacterial infection diagnosis and overall survival prediction in acute decompensation of liver cirrhosis
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T20%3A42%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Circulating%20microRNAs%20improve%20bacterial%20infection%20diagnosis%20and%20overall%20survival%20prediction%20in%20acute%20decompensation%20of%20liver%20cirrhosis&rft.jtitle=iScience&rft.au=Chouik,%20Yasmina&rft.date=2023-08-18&rft.volume=26&rft.issue=8&rft.spage=107427&rft.epage=107427&rft.pages=107427-107427&rft.artnum=107427&rft.issn=2589-0042&rft.eissn=2589-0042&rft_id=info:doi/10.1016/j.isci.2023.107427&rft_dat=%3Cproquest_doaj_%3E2850719309%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c556t-7559de973f12f14369b956a82cb8d2fe1ae6a99541047776b304844cf625daef3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2850719309&rft_id=info:pmid/37575179&rfr_iscdi=true