Two-Component Systems of Streptomyces coelicolor : An Intricate Network to Be Unraveled

Bacteria of the genus constitute an authentic biotech gold mine thanks to their ability to produce a myriad of compounds and enzymes of great interest at various clinical, agricultural, and industrial levels. Understanding the physiology of these organisms and revealing their regulatory mechanisms i...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-12, Vol.23 (23), p.15085
Main Authors: Sánchez de la Nieta, Ricardo, Santamaría, Ramón I, Díaz, Margarita
Format: Article
Language:English
Subjects:
Antibiotics
Bacteria
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
Biological activity
Biotechnology
Chromosomes
Environmental conditions
Gene expression
Gene Expression Regulation, Bacterial
Genomes
Homeostasis
Kinases
Metabolism
Microorganisms
molecular microbiology
Organisms
Phosphorylation
Prokaryotes
Proteins
Review
Signal Transduction
signal transduction and regulation
Streptomyces
Streptomyces - metabolism
Streptomyces coelicolor
Streptomyces coelicolor - genetics
Streptomyces coelicolor - metabolism
two-component systems
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Summary:Bacteria of the genus constitute an authentic biotech gold mine thanks to their ability to produce a myriad of compounds and enzymes of great interest at various clinical, agricultural, and industrial levels. Understanding the physiology of these organisms and revealing their regulatory mechanisms is essential for their manipulation and application. Two-component systems (TCSs) constitute the predominant signal transduction mechanism in prokaryotes, and can detect a multitude of external and internal stimuli and trigger the appropriate cellular responses for adapting to diverse environmental conditions. These global regulatory systems usually coordinate various biological processes for the maintenance of homeostasis and proper cell function. Here, we review the multiple TCSs described and characterized in , one of the most studied and important model species within this bacterial group. TCSs are involved in all cellular processes; hence, unravelling the complex regulatory network they form is essential for their potential biotechnological application.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms232315085