SARS-associated coronavirus transmission, United States

To better assess the risk for transmission of the severe acute respiratory syndrome-associated coronavirus (SARS-CoV), we obtained serial specimens and clinical and exposure data from seven confirmed U.S. SARS patients and their 10 household contacts. SARS-CoV was detected in a day-14 sputum specime...

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Bibliographic Details
Published in:Emerging infectious diseases 2004-02, Vol.10 (2), p.225-231
Main Authors: Isakbaeva, Elmira T, Khetsuriani, Nino, Beard, R Suzanne, Peck, Angela, Erdman, Dean, Monroe, Stephan S, Tong, Suxiang, Ksiazek, Thomas G, Lowther, Sara, Pandya-Smith, Indra, Anderson, Larry J, Lingappa, Jairam, Widdowson, Marc-Alain
Format: Article
Language:English
Subjects:
Adolescent
Adult
Child
Contact Tracing
Disease Outbreaks
epidemiology
Family Characteristics
Feces - virology
Female
Humans
Male
Middle Aged
natural history
outbreak
SARS coronavirus
SARS-associated coronavirus
severe acute respiratory syndrome (SARS)
Severe Acute Respiratory Syndrome - epidemiology
Severe Acute Respiratory Syndrome - transmission
Severe Acute Respiratory Syndrome - virology
Severe acute respiratory syndrome-related coronavirus - isolation & purification
Sputum - virology
Time Factors
transmission
United States - epidemiology
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Summary:To better assess the risk for transmission of the severe acute respiratory syndrome-associated coronavirus (SARS-CoV), we obtained serial specimens and clinical and exposure data from seven confirmed U.S. SARS patients and their 10 household contacts. SARS-CoV was detected in a day-14 sputum specimen from one case-patient and in five stool specimens from two case-patients. In one case-patient, SARS-CoV persisted in stool for at least 26 days after symptom onset. The highest amounts of virus were in the day-14 sputum sample and a day-14 stool sample. Residual respiratory symptoms were still present in recovered SARS case-patients 2 months after illness onset. Possible transmission of SARS-CoV occurred in one household contact, but this person had also traveled to a SARS-affected area. The data suggest that SARS-CoV is not always transmitted efficiently. Routine collection and testing of stool and sputum specimens of probable SARS case-patients may help the early detection of SARS-CoV infection.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid1002.030734