NT-proBNP independently predicts long term mortality after acute exacerbation of COPD - a prospective cohort study

• Published in: Respiratory research 2012-10, Vol.13 (1), p.97-97
• Main Authors: Høiseth, Arne Didrik, Omland, Torbjørn, Hagve, Tor-Arne, Brekke, Pål H, Søyseth, Vidar
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Analysis; Biomarkers - blood; Canada; Cardiac patients; Cardiovascular disease; Cardiovascular diseases; Chronic obstructive pulmonary disease; Cohort Studies; Complications and side effects; Diagnosis; Edema; Female; Follow-Up Studies; Genetic aspects; Health aspects; Heart; Heart attacks; Heart failure; Hostages; Humans; Longitudinal Studies; Lung diseases, Obstructive; Male; Medical research; Medicine, Experimental; Middle Aged; Mortality; Natriuretic Peptide, Brain - blood; Natriuretic peptides; Norway; NT-proBNP; Peptide Fragments - blood; Physiological aspects; Predictive Value of Tests; Prognosis; Prospective Studies; Pulmonary Disease, Chronic Obstructive - blood; Pulmonary Disease, Chronic Obstructive - diagnosis; Pulmonary Disease, Chronic Obstructive - mortality; Risk factors; Severity of Illness Index; Studies; Survival; Survival Rate; Time Factors
• ISSN: 1465-9921; 1465-993X; 1465-993X; 1465-9921
• DOI: 10.1186/1465-9921-13-97

Cardiovascular disease is prevalent and frequently unrecognized in patients with chronic obstructive pulmonary disease (COPD). NT-proBNP is an established risk factor in patients with heart failure. NT-proBNP may also be released from the right ventricle. Thus serum NT-proBNP may be elevated during acute exacerbations of COPD (AECOPD). The prognostic value of NT-proBNP in patients hospitalized with AECOPD is sparsely studied. Our objective was to test the hypothesis that NT-proBNP independently predicts long term mortality following AECOPD. A prospective cohort study of 99 patients with 217 admissions with AECOPD. Clinical, electrocardiographic, radiological and biochemical data were collected at index and repeat admissions and analyzed in an extended survival analysis with time-dependent covariables. Median follow-up time was 1.9 years, and 57 patients died during follow-up. NT-proBNP tertile limits were 264.4 and 909 pg/mL, and NT-proBNP in tertiles 1 through 3 was associated with mortality rates of 8.6, 35 and 62 per 100 patient-years, respectively (age-adjusted log-rank p