Disruptive Effect of Organotin on Thyroid Gland Function Might Contribute to Hypothyroidism

• Published in: International journal of endocrinology 2019-01, Vol.2019 (2019), p.1-8
• Main Authors: Moretto, Fernanda Cristina Fontes, Cardoso, Dariane Beatriz Marino, Tilli, Helena Paim, Freitas-Lima, Leandro Ceotto, Nogueira, Celia Regina, Síbio, Maria Teresa de, da Silva, Tabata Marinda, Costa, Sarah Maria Barneze, Gonçalves, Bianca Mariani, Graceli, Jones Bernardes, Olimpio, Regiane Marques Castro, Rodrigues, Bruna Moretto, de Oliveira, Miriane, Mathias, Lucas Solla
• Format: Article
• Language: English
• Subjects: Chemicals; Endocrine disruptors; Endocrine system; Endocrinology; Homeostasis; Hormones; Hyperplasia; Hypothalamus; Hypothyroidism; Invertebrates; Metabolism; Obesity; Physiological aspects; Physiology; Review; Thyroid gland; Thyroid hormones; Vertebrates; Wood preservatives; Zebrafish
• ISSN: 1687-8337; 1687-8345
• DOI: 10.1155/2019/7396716

A considerable increase in endocrine abnormalities has been reported over the last few decades worldwide. A growing exposure to endocrine-disrupting chemicals (EDCs) can be one of the causes of endocrine disorders in populations, and these disorders are not only restricted to the metabolic hormone system but can also cause abnormal functions. Thyroid hormone (TH) disruption is defined as an abnormal change in TH production, transport, function, or metabolism, which results in some degree of impairment in body homeostasis. Many EDCs, including organotin compounds (OTCs), are environmental contaminants that are commonly found in antifouling paints used on ships and in several other industrial procedures. OTCs are obesogenic and can disrupt TH metabolism; however, abnormalities in thyroid function resulting from OTC exposure are less well understood. OTCs, one of the most prevalent EDCs that are encountered on a daily basis, modulate the thyroid axis. In most toxicology studies, it has been reported that OTCs might contribute to hypothyroidism.