Lipid Droplet and Peroxisome Biogenesis: Do They Go Hand-in-Hand?

All eukaryotic cells contain membrane bound structures called organelles. Each organelle has specific composition and function. Some of the organelles are generated in a cell. The endoplasmic reticulum (ER) is a major contributor of proteins and membranes for most of the organelles. In this mini rev...

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Bibliographic Details
Published in:Frontiers in cell and developmental biology 2019-05, Vol.7, p.92-92
Main Authors: Joshi, Amit S, Cohen, Sarah
Format: Article
Language:English
Subjects:
lipid droplet
lipid metabolism
membrane trafficking
organelle biogenesis
peroxisome
Physiology
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Summary:All eukaryotic cells contain membrane bound structures called organelles. Each organelle has specific composition and function. Some of the organelles are generated in a cell. The endoplasmic reticulum (ER) is a major contributor of proteins and membranes for most of the organelles. In this mini review, we discuss biogenesis of two such organelles, peroxisomes and lipid droplets (LDs), that are formed in the ER membrane. LDs and peroxisomes are highly conserved ubiquitously present membrane-bound organelles. Both these organelles play vital roles in lipid metabolism and human health. Here, we discuss the current understanding of biogenesis of LDs and peroxisomes, recent advances on how biogenesis of both the organelles might be linked, physical interaction between LDs and peroxisomes and other organelles, and their physiological importance.
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2019.00092