The SERPINA4 rs2070777 AA Genotype is Associated with an Increased Risk of Recurrent Miscarriage in a Southern Chinese Population

Many inflammation-related gene polymorphisms are associated with susceptibility to recurrent miscarriage. is involved in inflammation and is associated with susceptibility to a variety of diseases, but its relevance in recurrent miscarriage is unclear. Therefore, this study aimed to investigate the...

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Bibliographic Details
Published in:International journal of women's health 2021-01, Vol.13, p.111-117
Main Authors: Che, Di, Fang, Zhenzhen, Pi, Lei, Xu, Yufen, Fu, LanYan, Zhou, Huazhong, Gu, Xiaoqiong
Format: Article
Language:English
Subjects:
Abortion, Habitual
Age
Angiogenesis
Apoptosis
Deoxyribonucleic acid
Disease susceptibility
DNA
Genes
Genetic aspects
genetic susceptibility
Genotype & phenotype
Inflammation
Investigations
Miscarriage
Original Research
polymorphism
Population
recurrent miscarriage
serpina4
Single nucleotide polymorphisms
Womens health
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Summary:Many inflammation-related gene polymorphisms are associated with susceptibility to recurrent miscarriage. is involved in inflammation and is associated with susceptibility to a variety of diseases, but its relevance in recurrent miscarriage is unclear. Therefore, this study aimed to investigate the relationship between gene polymorphisms and susceptibility to recurrent spontaneous abortion. Two polymorphisms were genotyped in 631 patients with recurrent miscarriage and 771 controls by TaqMan real-time polymerase chain reaction, and the strength of each association was evaluated through 95% confidence intervals (CIs) and odds ratios (ORs). The results showed that rs2070777 AA genotypes were associated with an increased risk of recurrent miscarriage (AA vs AT/TT adjusted OR=1.409, 95% CI=1.032-1.924, P=0.0309), and we also found a significant association between the rs910352 T allele in the gene and susceptibility to recurrent miscarriage (CT vs CC adjusted OR=1.579, 95% CI=1.252-1.992, P=0.0001; TT vs CC adjusted OR=1.524, 95% CI=1.134-2.049, P=0.0052). The combined analysis of two SNPs of the gene revealed that carriers with one to two unfavorable genotypes were associated with a higher risk for recurrent miscarriage compared with individuals with no unfavorable genotypes (adjusted OR=1.257, 95% CI=1.019-1.550). Moreover, our study indicates that having one to two unfavorable genotypes is associated with an increased risk of recurrent miscarriage in women 35-40 years of age. Our study suggests that rs2070777AA genotypes might contribute to an increased risk of recurrent miscarriage in a southern Chinese population.
ISSN:1179-1411
1179-1411
DOI:10.2147/IJWH.S290009