Liquid Biopsy in Head and Neck Cancer: Its Present State and Future Role in Africa

The rising mortality and morbidity rate of head and neck cancer (HNC) in Africa has been attributed to factors such as the poor state of health infrastructures, genetics, and late presentation resulting in the delayed diagnosis of these tumors. If well harnessed, emerging molecular and omics diagnos...

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Bibliographic Details
Published in:Cells (Basel, Switzerland) Switzerland), 2023-11, Vol.12 (22), p.2663
Main Authors: Temilola, Dada Oluwaseyi, Adeola, Henry Ademola, Grobbelaar, Johan, Chetty, Manogari
Format: Article
Language:English
Subjects:
Africa
Biomarkers
Biopsy
Blood platelets
Care and treatment
Cell adhesion & migration
Cell proliferation
cell-free DNA
Cerebrospinal fluid
circulating tumor cells
Demographic aspects
Diagnosis
Dielectric properties
DNA, Neoplasm
Event history analysis
Exocrine glands
Exosomes
Head & neck cancer
Head and neck cancer
Head and Neck Neoplasms - diagnosis
Health aspects
Humans
Liquid Biopsy
Lymphatic system
Lymphoma
Medical prognosis
Metastasis
Methods
Morbidity
RNA
Tumor cells
Tumors
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Summary:The rising mortality and morbidity rate of head and neck cancer (HNC) in Africa has been attributed to factors such as the poor state of health infrastructures, genetics, and late presentation resulting in the delayed diagnosis of these tumors. If well harnessed, emerging molecular and omics diagnostic technologies such as liquid biopsy can potentially play a major role in optimizing the management of HNC in Africa. However, to successfully apply liquid biopsy technology in the management of HNC in Africa, factors such as genetic, socioeconomic, environmental, and cultural acceptability of the technology must be given due consideration. This review outlines the role of circulating molecules such as tumor cells, tumor DNA, tumor RNA, proteins, and exosomes, in liquid biopsy technology for the management of HNC with a focus on studies conducted in Africa. The present state and the potential opportunities for the future use of liquid biopsy technology in the effective management of HNC in resource-limited settings such as Africa is further discussed.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells12222663