Role of myeloid cells in ischemic retinopathies: recent advances and unanswered questions

Myeloid cells including microglia and macrophages play crucial roles in retinal homeostasis by clearing cellular debris and regulating inflammation. These cells are activated in several blinding ischemic retinal diseases including diabetic retinopathy, where they may exert both beneficial and detrim...

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Bibliographic Details
Published in:Journal of neuroinflammation 2024-03, Vol.21 (1), p.65-20, Article 65
Main Authors: Shahror, Rami A, Morris, Carol A, Mohammed, Aya A, Wild, Melissa, Zaman, Bushra, Mitchell, Christian D, Phillips, Paul H, Rusch, Nancy J, Shosha, Esraa, Fouda, Abdelrahman Y
Format: Article
Language:English
Subjects:
Analysis
Angiogenesis
Blood vessels
Care and treatment
Diabetes mellitus
Diabetic Retinopathy
Diagnosis
Extracellular matrix
Homeostasis
Humans
Inflammation
Ischemia
Ischemia - pathology
Macrophages
Macrophages - pathology
Microglia
Myeloid cells
Neurophysiology
Optic nerve
Oxygen-induced retinopathy
Permeability
Photoreceptors
Retina
Retina - pathology
Retinal diseases
Retinal Diseases - pathology
Retinal ischemia
Retinopathy
Retinopathy of prematurity
Review
Roles
Veins & arteries
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Summary:Myeloid cells including microglia and macrophages play crucial roles in retinal homeostasis by clearing cellular debris and regulating inflammation. These cells are activated in several blinding ischemic retinal diseases including diabetic retinopathy, where they may exert both beneficial and detrimental effects on neurovascular function and angiogenesis. Myeloid cells impact the progression of retinal pathologies and recent studies suggest that targeting myeloid cells is a promising therapeutic strategy to mitigate diabetic retinopathy and other ischemic retinal diseases. This review summarizes the recent advances in our understanding of the role of microglia and macrophages in retinal diseases and focuses on the effects of myeloid cells on neurovascular injury and angiogenesis in ischemic retinopathies. We highlight gaps in knowledge and advocate for a more detailed understanding of the role of myeloid cells in retinal ischemic injury to fully unlock the potential of targeting myeloid cells as a therapeutic strategy for retinal ischemia.
ISSN:1742-2094
1742-2094
DOI:10.1186/s12974-024-03058-y