Elastin Barrier Membranes for Guided Tissue Regeneration Technologies

This article discusses the prospects for the use of new elastin barrier membranes manufactured using adapted technologies for the selective isolation of the elastin component from the extracellular xenogenic matrix of the pericardium ligamentous apparatus: (1) by high-temperature extraction under pr...

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Bibliographic Details
Published in:BIO web of conferences 2023-01, Vol.57, p.4002
Main Authors: Zvyagina, Alyona, Menukhov, Vladislav, Krasnova, Olga, Minaychev, Vladislav, Fadeeva, Irina
Format: Article
Language:English
Subjects:
Angiogenesis
Biocompatibility
Cyanogen
Elastin
High temperature
Membranes
Mesenchyme
Pericardium
Regeneration
Regeneration (physiology)
Repopulation
Tissue engineering
Tissues
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Summary:This article discusses the prospects for the use of new elastin barrier membranes manufactured using adapted technologies for the selective isolation of the elastin component from the extracellular xenogenic matrix of the pericardium ligamentous apparatus: (1) by high-temperature extraction under pressure; (2) cyanogen bromide method. A commercial material, Geistlich Bio–Gide® membrane (BG), was used as a control comparison group. It is shown that the materials of group (1) have a high degree of biocompatibility, exceeding the indicators of the control group BG. Based on the results of an study in a model of subcutaneous heterotopic implantation in rats, it was shown that elastin BM has a chemoattractant effect on the mesenchymal recipient cells and, unlike the control, is able to integrate to a high degree into the surrounding recipient tissues. At the same time, the materials of group (1) had a pronounced proangiogenic effect. Thus, it has been shown that elastin BM groups (1) have a medium-term barrier function and are able to induce full-fledged cellular repopulation and local neoangiogenesis, which can be useful in clinical practice, primarily in GTR technologies (with gingival flap augmentation) or when used together with other BM as an angiogenesis inducer to ensure formation of the vascular bed in GBR technologies of bone tissue.
ISSN:2117-4458
2273-1709
2117-4458
DOI:10.1051/bioconf/20235704002