Patterns and prognosis of regional recurrence in nasopharyngeal carcinoma after intensity‐modulated radiotherapy

Objective We analyzed the patterns of lymph node (LN) failure and prognosis in patients with regional recurrent nasopharyngeal carcinoma (rNPC) alone after primary intensity‐modulated radiotherapy (IMRT). Methods A total of 175 patients who were treated with IMRT between 2010 and 2015 and who experi...

Full description

Saved in:
Bibliographic Details
Published in:Cancer medicine (Malden, MA) MA), 2023-01, Vol.12 (2), p.1399-1408
Main Authors: Xiao, Xiao‐Tang, Wu, Yi‐Shan, Chen, Yu‐Pei, Liu, Xu, Guo, Rui, Tang, Ling‐Long, Ma, Jun, Li, Wen‐Fei
Format: Article
Language:English
Subjects:
Cancer therapies
Cartilage
Chemotherapy
Disease
Dissection
DNA viruses
Epstein-Barr virus
Epstein-Barr Virus Infections - pathology
Failure
failure pattern
Follow-Up Studies
Herpesvirus 4, Human
Histology
Humans
IMRT
Lymph nodes
Lymphatic system
Magnetic resonance imaging
Medical prognosis
Multivariate analysis
Nasopharyngeal carcinoma
Nasopharyngeal Carcinoma - pathology
Nasopharyngeal Carcinoma - radiotherapy
Nasopharyngeal Neoplasms - pathology
Neoplasm Recurrence, Local - pathology
Neoplasm Staging
Parotid gland
Patients
Prognosis
Radiation therapy
Radiotherapy, Intensity-Modulated - methods
regional recurrence
Retrospective Studies
Surgery
Throat cancer
Tomography
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective We analyzed the patterns of lymph node (LN) failure and prognosis in patients with regional recurrent nasopharyngeal carcinoma (rNPC) alone after primary intensity‐modulated radiotherapy (IMRT). Methods A total of 175 patients who were treated with IMRT between 2010 and 2015 and who experienced regional recurrence alone were included. Recurrent LNs were re‐located in the initial pretreatment imaging and IMRT plan and failures were classified as in‐field or out‐field based on target volume delineation. All patients underwent curative salvage treatment. Independent prognostic factors for overall survival (OS) were selected by multivariate Cox analysis. Results Level IIb (49.1%, 86/175) was the most frequent recurrence site, followed by level IIa (36%), level III (18.9%), level IVa (12%), the retropharyngeal region (8%), level Va (6.9%), and the parotid region (6.9%). A total of 264 recurrent LNs were recorded: 149 (56.4%) were classified as in‐field failure with a prescribed dose ≥66 Gy, 60 (22.7%) with 60 to
ISSN:2045-7634
2045-7634
DOI:10.1002/cam4.5020