Inhibition of A/Human/Hubei/3/2005 (H3N2) influenza virus infection by silver nanoparticles in vitro and in vivo

Silver nanoparticles (AgNPs) have attracted much attention as antimicrobial agents and have demonstrated efficient inhibitory activity against various viruses, including human immunodeficiency virus, hepatitis B virus, and Tacaribe virus. In this study, we investigated if AgNPs could have antiviral...

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Bibliographic Details
Published in:International journal of nanomedicine 2013-01, Vol.8 (1), p.4103-4114
Main Authors: Xiang, Dongxi, Zheng, Yang, Duan, Wei, Li, Xiujing, Yin, Jianjian, Shigdar, Sarah, O'Connor, Michael Liam, Marappan, Manju, Zhao, Xiaojuan, Miao, Yingqiu, Xiang, Bin, Zheng, Conglong
Format: Article
Language:English
Subjects:
Administration, Intranasal
Analysis of Variance
Animals
Antimicrobial agents
antiviral activity
Antiviral Agents - administration & dosage
Antiviral Agents - chemistry
Antiviral Agents - pharmacology
Apoptosis - drug effects
Cell Survival - drug effects
Comparative analysis
Dogs
Drug therapy
Female
H3N2
Health aspects
Hepatitis B virus
Infections
Influenza
Influenza A Virus, H3N2 Subtype - drug effects
influenza virus
Lung - virology
Madin Darby Canine Kidney Cells
Metal Nanoparticles - administration & dosage
Metal Nanoparticles - chemistry
Mice
Mice, Inbred BALB C
Nanoparticles
Original Research
Silver
Silver - pharmacology
silver nanoparticles
Viruses
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Summary:Silver nanoparticles (AgNPs) have attracted much attention as antimicrobial agents and have demonstrated efficient inhibitory activity against various viruses, including human immunodeficiency virus, hepatitis B virus, and Tacaribe virus. In this study, we investigated if AgNPs could have antiviral and preventive effects in A/Human/Hubei/3/2005 (H3N2) influenza virus infection. Madin-Darby canine kidney cells infected with AgNP-treated H3N2 influenza virus showed better viability (P
ISSN:1178-2013
1176-9114
1178-2013
DOI:10.2147/ijn.s53622