Relevance of Nerve Biopsy in the Diagnosis of Chronic Inflammatory Demyelinating Polyneuropathy—A Systematic Review

Chronic Inflammatory Demyelinating Polyneuropathy is an immune-mediated pathology of the peripheral nerves and nerve roots that leads to weakness and sensory symptoms. Given its clinical heterogeneity, often times diagnosis is challenging. Even though nerve conduction studies and clinical features a...

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Bibliographic Details
Published in:Diagnostics (Basel) 2022-07, Vol.12 (7), p.1691
Main Authors: Moise, Elena-Sonia, Bratu, Razvan Matei, Hanganu, Andreea, Sajin, Maria
Format: Article
Language:English
Subjects:
Biopsy
chronic inflammatory demyelinating polyneuropathy
Disease
Microscopy
nerve biopsy
Nervous system
Systematic Review
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Summary:Chronic Inflammatory Demyelinating Polyneuropathy is an immune-mediated pathology of the peripheral nerves and nerve roots that leads to weakness and sensory symptoms. Given its clinical heterogeneity, often times diagnosis is challenging. Even though nerve conduction studies and clinical features are the main criteria used for diagnosis, supplementary investigations, such as nerve biopsies, cerebral spinal fluid examination and magnetic resonance studies, may be used in order to confirm the diagnosis. Given the fact that the hallmark in CIDP physiopathology is the demyelination process, nerve biopsies are used to demonstrate and assess the magnitude of the phenomenon. The question and the main interest of this review is whether histopathological findings are relevant for the diagnosis and can be useful in disease assessment.
ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics12071691