The Association of Serum Anti-Lysosomal-Associated Membrane Protein-2 Antibody with Vasculitis Combined with Hypertension

The aim of this study was to explore the association of serum anti-lysosomal-associated membrane protein-2 (anti-LAMP-2) antibody with vasculitis combined with hypertension (VAS-HTN). A total of 51 VAS-HTN patients, 46 essential hypertension (EH) patients, and 46 healthy controls (HC) were included...

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Published in:International journal of hypertension 2022-03, Vol.2022, p.9656560-9
Main Authors: Zhu, Bin, Cai, Xintian, Zhu, Qing, Wu, Ting, Liu, Shasha, Liu, Shanshan, Hong, Jing, Li, Nanfang
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Language:English
Subjects:
Antibodies
C-reactive protein
Comparative analysis
Data collection
Disease
Hematuria
Hypertension
Laboratories
Medical research
Medicine, Experimental
Proteins
Software
Standard deviation
Statistical analysis
Urine
Vasculitis
Viral antibodies
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container_title International journal of hypertension
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description The aim of this study was to explore the association of serum anti-lysosomal-associated membrane protein-2 (anti-LAMP-2) antibody with vasculitis combined with hypertension (VAS-HTN). A total of 51 VAS-HTN patients, 46 essential hypertension (EH) patients, and 46 healthy controls (HC) were included in the study. Serum anti-LAMP-2 antibody levels are increased in VAS-HTN patients as compared with EH and HC (all P
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A total of 51 VAS-HTN patients, 46 essential hypertension (EH) patients, and 46 healthy controls (HC) were included in the study. Serum anti-LAMP-2 antibody levels are increased in VAS-HTN patients as compared with EH and HC (all P<0.05). Serum anti-LAMP-2 antibody levels were significantly higher in active stage patients than those in non-active stage patients and HC (all P<0.05). The correlation analysis showed a significant positive correlation between serum anti-LAMP-2 antibody levels and the Birmingham Vasculitis Activity Score (BVAS) and hypersensitive C-reactive protein (Hs-CRP) (all P<0.05). Among the subsets of VAS-HTN, the levels of serum anti-LAMP-2 antibody were remarkably higher in all VAS-HTN subsets compared with HC (all P<0.05). More interestingly, the levels of serum anti-LAMP-2 antibody were remarkably increased in polyarteritis nodosa (PAN) patients compared with ANCA-associated vasculitis and Takayasu arteritis patients (all P<0.05). In addition, there was a significant positive correlation between serum anti-LAMP-2 antibody levels and BAVS and Hs-CRP in PAN patients (all P<0.05). Multivariate logistic regression analysis showed that the anti-LAMP-2 antibody was independently associated with VAS-HTN. The levels of serum anti-LAMP-2 antibody were remarkably increased in VAS-HTN patients compared to EH and HC and might reflect the disease activity. The anti-LAMP-2 antibody may be a potential biomarker for diagnosis and estimating the disease activity in VAS-HTN.]]></description><identifier>ISSN: 2090-0384</identifier><identifier>ISSN: 2090-0392</identifier><identifier>EISSN: 2090-0392</identifier><identifier>DOI: 10.1155/2022/9656560</identifier><identifier>PMID: 35356030</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Antibodies ; C-reactive protein ; Comparative analysis ; Data collection ; Disease ; Hematuria ; Hypertension ; Laboratories ; Medical research ; Medicine, Experimental ; Proteins ; Software ; Standard deviation ; Statistical analysis ; Urine ; Vasculitis ; Viral antibodies</subject><ispartof>International journal of hypertension, 2022-03, Vol.2022, p.9656560-9</ispartof><rights>Copyright © 2022 Bin Zhu et al.</rights><rights>COPYRIGHT 2022 John Wiley &amp; Sons, Inc.</rights><rights>Copyright © 2022 Bin Zhu et al. 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A total of 51 VAS-HTN patients, 46 essential hypertension (EH) patients, and 46 healthy controls (HC) were included in the study. Serum anti-LAMP-2 antibody levels are increased in VAS-HTN patients as compared with EH and HC (all P<0.05). Serum anti-LAMP-2 antibody levels were significantly higher in active stage patients than those in non-active stage patients and HC (all P<0.05). The correlation analysis showed a significant positive correlation between serum anti-LAMP-2 antibody levels and the Birmingham Vasculitis Activity Score (BVAS) and hypersensitive C-reactive protein (Hs-CRP) (all P<0.05). Among the subsets of VAS-HTN, the levels of serum anti-LAMP-2 antibody were remarkably higher in all VAS-HTN subsets compared with HC (all P<0.05). More interestingly, the levels of serum anti-LAMP-2 antibody were remarkably increased in polyarteritis nodosa (PAN) patients compared with ANCA-associated vasculitis and Takayasu arteritis patients (all P<0.05). 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A total of 51 VAS-HTN patients, 46 essential hypertension (EH) patients, and 46 healthy controls (HC) were included in the study. Serum anti-LAMP-2 antibody levels are increased in VAS-HTN patients as compared with EH and HC (all P<0.05). Serum anti-LAMP-2 antibody levels were significantly higher in active stage patients than those in non-active stage patients and HC (all P<0.05). The correlation analysis showed a significant positive correlation between serum anti-LAMP-2 antibody levels and the Birmingham Vasculitis Activity Score (BVAS) and hypersensitive C-reactive protein (Hs-CRP) (all P<0.05). Among the subsets of VAS-HTN, the levels of serum anti-LAMP-2 antibody were remarkably higher in all VAS-HTN subsets compared with HC (all P<0.05). More interestingly, the levels of serum anti-LAMP-2 antibody were remarkably increased in polyarteritis nodosa (PAN) patients compared with ANCA-associated vasculitis and Takayasu arteritis patients (all P<0.05). In addition, there was a significant positive correlation between serum anti-LAMP-2 antibody levels and BAVS and Hs-CRP in PAN patients (all P<0.05). Multivariate logistic regression analysis showed that the anti-LAMP-2 antibody was independently associated with VAS-HTN. The levels of serum anti-LAMP-2 antibody were remarkably increased in VAS-HTN patients compared to EH and HC and might reflect the disease activity. The anti-LAMP-2 antibody may be a potential biomarker for diagnosis and estimating the disease activity in VAS-HTN.]]></abstract><cop>United States</cop><pub>Hindawi</pub><pmid>35356030</pmid><doi>10.1155/2022/9656560</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-3172-1540</orcidid><orcidid>https://orcid.org/0000-0002-8842-4558</orcidid><orcidid>https://orcid.org/0000-0002-8611-189X</orcidid><orcidid>https://orcid.org/0000-0003-1505-8566</orcidid><oa>free_for_read</oa></addata></record>
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subjects Antibodies
C-reactive protein
Comparative analysis
Data collection
Disease
Hematuria
Hypertension
Laboratories
Medical research
Medicine, Experimental
Proteins
Software
Standard deviation
Statistical analysis
Urine
Vasculitis
Viral antibodies
title The Association of Serum Anti-Lysosomal-Associated Membrane Protein-2 Antibody with Vasculitis Combined with Hypertension
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