Association between immunoglobulin A and depression in Chinese older adults: findings from a cross-sectional study

• Published in: Immunity & ageing 2022-05, Vol.19 (1), p.21-21, Article 21
• Main Authors: Sun, Zhigao, Lin, Jieqiong, Zhang, Yujie, Yao, Yao, Huang, Zhenjun, Zhao, Yali, Zhang, Pei, Fu, Shihui
• Format: Article
• Language: English
• Subjects: Aged; Brief Report; China; Depression; Depression, Mental; Epidemiology; GDS-15; Immunoglobulin A; Medical research; Medicine, Experimental; Older adults; Surveys
• ISSN: 1742-4933; 1742-4933
• DOI: 10.1186/s12979-022-00283-y

Depression is considered to be an immune-related disease; however, previous studies have focused on inflammatory factors, and there is no conclusive conclusion on the relationships between immunoglobulins and depression. Therefore, the objective of this cross-sectional study was to evaluate the associations between immunoglobulins and depressive symptoms in Chinese older adults. The China Hainan Centenarian Cohort Study (CHCCS) provides a significant population-based sample of older adults in Hainan, China. A total of 1547 older adults were included in this study. A baseline survey was conducted using a structured questionnaire. Blood samples were obtained following standard procedures. The Geriatric Depression Scale (GDS-15) was used to evaluate depressive symptoms of the participants. This sample of older adults had a median age of 94.75 (range: 80-116) years, and the proportion of women was 72.07%. The prevalence of older adults with depressive symptoms was 20.36% (315 older adults). After adjusting for all covariates, we found that immunoglobulin A levels were positively associated with depression. The adjusted reliability of the association between immunoglobulin A and depression was 0.106 (beta) and 1.083 (odds ratio) (P