Iron Oxide Nanoparticles for Biomedical Applications: A Perspective on Synthesis, Drugs, Antimicrobial Activity, and Toxicity

Medical applications and biotechnological advances, including magnetic resonance imaging, cell separation and detection, tissue repair, magnetic hyperthermia and drug delivery, have strongly benefited from employing iron oxide nanoparticles (IONPs) due to their remarkable properties, such as superpa...

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Bibliographic Details
Published in:Antibiotics (Basel) 2018-06, Vol.7 (2), p.46
Main Authors: Arias, Laís Salomão, Pessan, Juliano Pelim, Vieira, Ana Paula Miranda, Lima, Taynara Maria Toito de, Delbem, Alberto Carlos Botazzo, Monteiro, Douglas Roberto
Format: Article
Language:English
Subjects:
Antiinfectives and antibacterials
Antimicrobial activity
Antimicrobial agents
Biocompatibility
Biomedical materials
biotechnology
Clinical trials
Dentistry
Drug delivery
Drug delivery systems
Hyperthermia
iron oxide nanoparticles
Iron oxides
magnetic nanoparticles
Magnetic resonance imaging
Methods
Microemulsions
Microorganisms
Nanoparticles
Nanotechnology
Oxidative stress
Protective coatings
Review
Side effects
Surfactants
Synthesis
Temperature
Toxicity
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Summary:Medical applications and biotechnological advances, including magnetic resonance imaging, cell separation and detection, tissue repair, magnetic hyperthermia and drug delivery, have strongly benefited from employing iron oxide nanoparticles (IONPs) due to their remarkable properties, such as superparamagnetism, size and possibility of receiving a biocompatible coating. Ongoing research efforts focus on reducing drug concentration, toxicity, and other side effects, while increasing efficacy of IONPs-based treatments. This review highlights the methods of synthesis and presents the most recent reports in the literature regarding advances in drug delivery using IONPs-based systems, as well as their antimicrobial activity against different microorganisms. Furthermore, the toxicity of IONPs alone and constituting nanosystems is also addressed.
ISSN:2079-6382
2079-6382
DOI:10.3390/antibiotics7020046