New Iridoid Glucosides from Caryopteris incana (Thunb.) Miq. and Their α-Glucosidase Inhibitory Activities

In our continued investigations of the plant , five new iridoid glucosides - , including two -isomers, and , along with six known compounds - , were isolated from the -butyl alcohol ( -BuOH) soluble fraction of whole dried material of . Their structures were established by a combination of spectrosc...

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Published in:Molecules (Basel, Switzerland) Switzerland), 2016-12, Vol.21 (12), p.1749-1749
Main Authors: Mao, Xu-Dong, Chou, Gui-Xin, Zhao, Sen-Miao, Zhang, Cheng-Gang
Format: Article
Language:English
Subjects:
1-Butanol - chemistry
alpha-Glucosidases - chemistry
Carbohydrate Conformation
Caryopteris incana
Glycoside Hydrolase Inhibitors - chemistry
Glycoside Hydrolase Inhibitors - isolation & purification
Humans
iridoid glucosides
Iridoid Glucosides - chemistry
Iridoid Glucosides - isolation & purification
Lamiaceae - chemistry
Plant Extracts - chemistry
Solvents - chemistry
type-II diabetes mellitus
α-glucosidase inhibition
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Summary:In our continued investigations of the plant , five new iridoid glucosides - , including two -isomers, and , along with six known compounds - , were isolated from the -butyl alcohol ( -BuOH) soluble fraction of whole dried material of . Their structures were established by a combination of spectroscopic techniques, including 1D and 2D NMR and high resolution electrospray ionization mass spectroscopy (HR-ESI-MS). Furthermore, all isolates were evaluated for their yeast α-glucosidase inhibitory effects. Among these compounds, - and exhibited potent inhibition of α-glucosidase.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules21121749