Molecular Epidemiology of Human Adenovirus-Associated Febrile Respiratory Illness in Soldiers, South Korea

During January 2013–April 2014, we subjected nasopharyngeal specimens collected from patients with acute febrile respiratory illness in a military hospital to PCR testing to detect 12 respiratory viruses and sequence a partial hexon gene for human adenovirus (HAdV) molecular typing. We analyzed the...

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Bibliographic Details
Published in:Emerging infectious diseases 2018-07, Vol.24 (7), p.1221-1227
Main Authors: Heo, Jung Yeon, Noh, Ji Yun, Jeong, Hye Won, Choe, Kang-Won, Song, Joon Young, Kim, Woo Joo, Cheong, Hee Jin
Format: Article
Language:English
Subjects:
adenovirus infections
Adenoviruses
Comparative analysis
Diagnosis
Epidemiology
HAdV
Health aspects
human
Military hospitals
military personnel
Pneumonia
respiratory tract infections
Soldiers
Viral proteins
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Summary:During January 2013–April 2014, we subjected nasopharyngeal specimens collected from patients with acute febrile respiratory illness in a military hospital to PCR testing to detect 12 respiratory viruses and sequence a partial hexon gene for human adenovirus (HAdV) molecular typing. We analyzed the epidemiologic characteristics of HAdV infections and compared clinical characteristics of HAdV types. Among the 305 patients with acute febrile respiratory illness, we detected respiratory viruses in 139 (45.6%) patients; HAdV was the most prevalent virus (69 cases). Of the 40 adenoviruses identified based on type, HAdV-55 (29 cases) was the most prevalent, followed by HAdV-4 (9 cases). HAdV-55 was common in patients with pneumonia (odds ratio 2.17; 95% CI 0.48–9.86) and hospitalized patients (odds ratio 5.21; 95% CI 1.06–25.50). In soldiers with HAdV infection in Korea, HAdV-55 was the most prevalent type and might be associated with severe clinical outcomes.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid2407.171222