Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes

Previous studies suggest that children who progress to type 1 diabetes (T1D) later in life already have an altered serum lipid molecular profile at birth. Here, we compared cord blood lipidome across the three study groups: children who progressed to T1D (PT1D; = 30), children who developed at least...

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Bibliographic Details
Published in:Biomolecules (Basel, Switzerland) Switzerland), 2019-01, Vol.9 (1), p.33
Main Authors: Lamichhane, Santosh, Ahonen, Linda, Dyrlund, Thomas Sparholt, Dickens, Alex M, Siljander, Heli, Hyöty, Heikki, Ilonen, Jorma, Toppari, Jorma, Veijola, Riitta, Hyötyläinen, Tuulia, Knip, Mikael, Oresic, Matej
Format: Article
Language:English
Subjects:
Accuracy
Area Under Curve
Autoantibodies
Autoantibodies - analysis
Autoimmunity
Case-Control Studies
Child
Child, Preschool
Children
Cholesterol
Chromatography, High Pressure Liquid
Cord blood
Diabetes
Diabetes mellitus (insulin dependent)
Diabetes Mellitus, Type 1 - pathology
Discriminant Analysis
Disease prevention
Disease Progression
Esters
Female
Fetal Blood - metabolism
Humans
Islets of Langerhans - immunology
Least-Squares Analysis
lipidomics
Lipids
Lipids - analysis
Male
Mass Spectrometry
Medicin och hälsovetenskap
metabolomics
Newborn babies
Performance evaluation
Phospholipids
Principal components analysis
ROC Curve
Signatures
Sphingomyelins - metabolism
type 1 diabetes
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Summary:Previous studies suggest that children who progress to type 1 diabetes (T1D) later in life already have an altered serum lipid molecular profile at birth. Here, we compared cord blood lipidome across the three study groups: children who progressed to T1D (PT1D; = 30), children who developed at least one islet autoantibody but did not progress to T1D during the follow-up (P1Ab; = 33), and their age-matched controls (CTR; = 38). We found that phospholipids, specifically sphingomyelins, were lower in T1D progressors when compared to P1Ab and the CTR. Cholesterol esters remained higher in PT1D when compared to other groups. A signature comprising five lipids was predictive of the risk of progression to T1D, with an area under the receiver operating characteristic curve (AUROC) of 0.83. Our findings provide further evidence that the lipidomic profiles of newborn infants who progress to T1D later in life are different from lipidomic profiles in P1Ab and CTR.
ISSN:2218-273X
2218-273X
DOI:10.3390/biom9010033