Magnesium-Containing Silicate Bioceramic Degradable Intramedullary Nail for Bone Fractures

Intramedullary nails (INs) have significant advantages in rigid fracture fixation. Due to the stress shielding effect and lack of biological activity, traditional metal INs often lead to delay union or nonunion fracture healing. Undegradable metals also need to be removed by a second surgery, which...

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Bibliographic Details
Published in:Crystals (Basel) 2022-07, Vol.12 (7), p.974
Main Authors: Ye, Yuxiang, Shao, Huifeng, Jing, Zhuoluo, Nian, Zhiheng, Gong, Youping
Format: Article
Language:English
Subjects:
Bend strength
Bins
bioceramic
Bioceramics
Biodegradability
Biodegradation
Biological activity
Biological effects
Biomedical materials
fracture
Fractures
Freeze drying
High strength
Intramedullary nails
Magnesium
magnesium-containing silicate
Manufacturing
Mechanical properties
Particle size
Polyvinyl alcohol
Production methods
Sintering
Stress shielding
Tissues
Titanium alloys
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Summary:Intramedullary nails (INs) have significant advantages in rigid fracture fixation. Due to the stress shielding effect and lack of biological activity, traditional metal INs often lead to delay union or nonunion fracture healing. Undegradable metals also need to be removed by a second surgery, which will impose a potential risk to the patient. Current degradable biomaterials with low strength cannot be used in INs. Manufacturing high-strength biodegradable INs (BINs) is still a challenge. Here, we reported a novel high strength bioactive magnesium-containing silicate (CSi-Mg) BIN. This BIN is manufactured by using casting, freeze drying, and sintering techniques and has extremely high bending strength and stable internal and external structures. The manufacturing parameters were systematically studied, such as the paste component, freeze-drying process, and sintering process. This manufacturing method can be applied to various sizes of BINs. The CSi-Mg BIN also has good bioactivity and biodegradation properties. This novel bioactive BIN is expected to replace the traditional metal INs and become a more effective way of treating fractures.
ISSN:2073-4352
2073-4352
DOI:10.3390/cryst12070974