Cerebellar atrophy related to chronic exposure to toluene. Case report

A 31-year-old woman presented slowly progressing ataxia and neurasthenic symptoms after 14-year occupational exposure to low concentration toluene vapour. Examination disclosed only cerebellar signs. Cognitive functions were normal except moderate visuo-spatial and constructive deficit. CT imaging s...

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Bibliographic Details
Published in:Arquivos de neuro-psiquiatria 1994-03, Vol.52 (1), p.90-92
Main Authors: Damasceno, B P, de Capitani, E M
Format: Article
Language:English
Subjects:
Adult
atrofia cerebelar
Atrophy - cerebrospinal fluid
Atrophy - chemically induced
Atrophy - diagnostic imaging
Cerebellum - diagnostic imaging
Cerebellum - pathology
Cerebellum - physiopathology
Female
Humans
NEUROSCIENCES
neurotoxicidade
Occupational Exposure - adverse effects
PSYCHIATRY
solventes orgânicos
Toluene - adverse effects
tolueno
Tomography, X-Ray Computed
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Description
Summary:A 31-year-old woman presented slowly progressing ataxia and neurasthenic symptoms after 14-year occupational exposure to low concentration toluene vapour. Examination disclosed only cerebellar signs. Cognitive functions were normal except moderate visuo-spatial and constructive deficit. CT imaging showed severe pancerebellar atrophy without pathological signs in other brain structures. Two years after she was removed from workplace, CT imaging and ataxia showed no worsening, while visuo-constructive function improved. The authors warn against possible neurotoxic risk associated with this kind of exposure.
ISSN:0004-282X
1678-4227
0004-282X
DOI:10.1590/S0004-282X1994000100017