Dose–Response of Creatine Supplementation on Cognitive Function in Healthy Young Adults

To determine if creatine (Cr) supplementation could influence cognitive performance and whether any changes were related to changes in prefrontal cortex (PFC) activation during such cognitive tasks, thirty (M = 11, F = 19) participants were evenly randomized to receive supplementation with Cr (CR10:...

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Bibliographic Details
Published in:Brain sciences 2023-09, Vol.13 (9), p.1276
Main Authors: Moriarty, Terence, Bourbeau, Kelsey, Dorman, Katie, Runyon, Lance, Glaser, Noah, Brandt, Jenna, Hoodjer, Mallory, Forbes, Scott C, Candow, Darren G
Format: Article
Language:English
Subjects:
Adenosine triphosphatase
Adenosine triphosphate
Body composition
Brain research
Cognition & reasoning
Cognitive ability
cognitive function
Creatine
Energy consumption
Exercise
functional near-infrared spectroscopy
Information processing
Infrared spectroscopy
Investigations
Kinases
Memory
Metabolism
Muscle proteins
Musculoskeletal system
Nervous system
Neurophysiology
NMR
Nuclear magnetic resonance
oxygenated hemoglobin
Physical fitness
Prefrontal cortex
Questionnaires
Spectrum analysis
Supplements
Teenagers
Vegetarianism
Young adults
Youth
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Summary:To determine if creatine (Cr) supplementation could influence cognitive performance and whether any changes were related to changes in prefrontal cortex (PFC) activation during such cognitive tasks, thirty (M = 11, F = 19) participants were evenly randomized to receive supplementation with Cr (CR10:10 g/day or CR20:20 g/day) or a placebo (PLA:10 g/day) for 6 weeks. Participants completed a cognitive test battery (processing speed, episodic memory, and attention) on two separate occasions prior to and following supplementation. Functional near-infrared spectroscopy (fNIRS) was used to measure PFC oxyhemoglobin (O2Hb) during the cognitive evaluation. A two-way repeated measures ANOVA was used to determine the differences between the groups and the timepoints for the cognitive performance scores and PFC O2Hb. In addition, a one-way ANOVA of % change was used to determine pre- and post-differences between the groups. Creatine (independent of dosage) had no significant effect on the measures of cognitive performance. There was a trend for decreased relative PFC O2Hb in the CR10 group versus the PLA group in the processing speed test (p = 0.06). Overall, six weeks of Cr supplementation at a moderate or high dose does not improve cognitive performance or change PFC activation in young adults.
ISSN:2076-3425
2076-3425
DOI:10.3390/brainsci13091276