Effects of the interactions between platelets with other cells in tumor growth and progression

It has been confirmed that platelets play a key role in tumorigenesis. Tumor-activated platelets can recruit blood cells and immune cells to migrate, establish an inflammatory tumor microenvironment at the sites of primary and metastatic tumors. On the other hand, they can also promote the different...

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Bibliographic Details
Published in:Frontiers in immunology 2023-04, Vol.14, p.1165989-1165989
Main Authors: Li, Yaxin, Wang, Haiyan, Zhao, Zhen, Yang, Yuanming, Meng, Zifan, Qin, Lifeng
Format: Article
Language:English
Subjects:
Blood Platelets
Carcinogenesis - pathology
Cell Transformation, Neoplastic - pathology
Humans
immune cells
Immunology
interaction
Monocytes - pathology
Neoplasms
platelets
tumor development
Tumor Microenvironment
tumorigenesis
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Summary:It has been confirmed that platelets play a key role in tumorigenesis. Tumor-activated platelets can recruit blood cells and immune cells to migrate, establish an inflammatory tumor microenvironment at the sites of primary and metastatic tumors. On the other hand, they can also promote the differentiation of mesenchymal cells, which can accelerate the proliferation, genesis and migration of blood vessels. The role of platelets in tumors has been well studied. However, a growing number of studies suggest that interactions between platelets and immune cells (e.g., dendritic cells, natural killer cells, monocytes, and red blood cells) also play an important role in tumorigenesis and tumor development. In this review, we summarize the major cells that are closely associated with platelets and discuss the essential role of the interaction between platelets with these cells in tumorigenesis and tumor development.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2023.1165989