Chemical Composition, Antifungal and Insecticidal Activities of the Essential Oils from Tunisian Clinopodium Nepeta Subsp. nepeta and Clinopodium Nepeta Subsp. Glandulosum

The present investigation was focused on the study of the chemical composition variability and biological activities of the essential oils from subsp. and subsp. . Essential oils extraction was performed using hydrodistillation and the separation of the constituents was carried out by gas chromatogr...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2020-05, Vol.25 (9), p.2137
Main Authors: Debbabi, Haïfa, Mokni, Ridha El, Chaieb, Ikbal, Nardoni, Simona, Maggi, Filippo, Caprioli, Giovanni, Hammami, Saoussen
Format: Article
Language:English
Subjects:
Antifungal Agents - chemistry
Antifungal Agents - pharmacology
biological activities
chemical variability
Clinopodium nepeta subsp. glandulosum
Clinopodium nepeta subsp. nepeta
essential oils
Gas Chromatography-Mass Spectrometry
Insecticides - chemistry
Insecticides - pharmacology
Lamiaceae
Lamiaceae - chemistry
Microbial Sensitivity Tests
Oils, Volatile - chemistry
Oils, Volatile - pharmacology
Phytochemicals - chemistry
Phytochemicals - pharmacology
Plant Oils - chemistry
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Summary:The present investigation was focused on the study of the chemical composition variability and biological activities of the essential oils from subsp. and subsp. . Essential oils extraction was performed using hydrodistillation and the separation of the constituents was carried out by gas chromatography coupled with mass spectrometry (GC-MS). Antifungal activities were tested against , , , and . Toxicity and repellency were evaluated against the stored product pests and . Both essential oils were characterized by a high content of oxygenated monoterpenes. Piperitone ranks first in the subspecies and piperitenone oxide is the dominant constituent in the subspecies . All tested samples displayed noteworthy antifungal properties, with the highest activity observed for the essential oil of subsp. , collected in Béni-M'tir, against (MIC = 40 µg/mL). The essential oil samples of subsp. were strongly repellent to the insect species (PR > 80%, after 2h) and highly toxic to reaching 97.5%-100% mortality after 24 h of exposure. In conclusion, this study showed considerable intra-specific changes in the quality of essential oils, which is reflected in different rates of antifungal and insecticidal activity.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules25092137