Association of Helicobacter pylori Infection with Coronary Artery Disease: Is Helicobacter pylori a Risk Factor?

Background. Helicobacter pylori (HP) infection is the most common infection in the world and coronary artery disease (CAD) is probably associated with it. The aim of this prospective study was to evaluate the association between HP infection and CAD in suspected patients referred for coronary angiog...

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Bibliographic Details
Published in:TheScientificWorld 2014-01, Vol.2014 (2014), p.1-6
Main Authors: Sattari, Mohammadamin, Vahedian, Mostafa, Damanpak, Vahid, Hejazi, Seyyed Fakhroldin, Vafaeimanesh, Jamshid, Seyyed Majidi, Mohammad Reza
Format: Article
Language:English
Subjects:
Adult
Anemia
Antibodies, Bacterial - blood
C-Reactive Protein - metabolism
Cardiovascular disease
Cholesterol
Coronary Angiography
Coronary Artery Disease - blood
Coronary Artery Disease - complications
Coronary Artery Disease - diagnostic imaging
Coronary Artery Disease - epidemiology
Coronary heart disease
Development and progression
Drug therapy
Helicobacter infections
Helicobacter Infections - blood
Helicobacter Infections - complications
Helicobacter Infections - diagnostic imaging
Helicobacter Infections - epidemiology
Helicobacter pylori
Host-parasite relationships
Humans
Immunoglobulin G - blood
Lipoproteins, HDL - blood
Male
Middle Aged
Prevalence
Prospective Studies
Research Article
Risk Factors
Studies
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Summary:Background. Helicobacter pylori (HP) infection is the most common infection in the world and coronary artery disease (CAD) is probably associated with it. The aim of this prospective study was to evaluate the association between HP infection and CAD in suspected patients referred for coronary angiography. The coronary angiography was performed using Judkins method and patients were assigned to participate in CAD positive (>50% luminal diameter stenosis) and negative groups. The serum HP IgG antibody was checked. Results. Positive and negative CAD groups consisted of 62 and 58 patients, respectively. HP was more prevalent among CAD+ patients, and with increasing the number of coronary arteries with stenosis, the HP seropositivity increased so that 76.3% of patients with multiple vessel diseases (MVD) and 70% of patients with single vessel diseases (SVD) were HP seropositive versus 50% in control group (P=0.006). Positive CAD was significantly associated with HDL level (P=0.01) and ESR level (P=0.006). Also, CAD+ patients had higher CRP levels than controls and it was statistically different between SVD group and controls (P
ISSN:2356-6140
1537-744X
1537-744X
DOI:10.1155/2014/516354