Exploratory Cortex Metabolic Profiling Revealed the Sedative Effect of Amber in Pentylenetetrazole-Induced Epilepsy-Like Mice

Epilepsy is a common clinical syndrome characterized by sudden and recurrent attacks and temporary central nervous system dysfunction caused by excessive discharge of neurons in the brain. Amber, a fossilized organic substance formed by the resins of conifers and leguminous plants, was prescribed to...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2019-01, Vol.24 (3), p.460
Main Authors: Zhu, Zhenhua, Chen, Chenkai, Zhu, Yue, Shang, Erxin, Zhao, Ming, Guo, Sheng, Guo, Jianming, Qian, Dawei, Tang, Zhishu, Yan, Hui, Duan, Jinao
Format: Article
Language:English
Subjects:
Alzheimer's disease
Amber
Anesthesia
Biomarkers
Central nervous system
Chinese medicine
Chromatography
Conifers
Convulsions & seizures
Discriminant analysis
Epilepsy
Fossils
glycerophospholipid metabolism
LC/MS
Leguminous plants
Metabolism
Metabolites
Metabolomics
Multivariate statistical analysis
Network analysis
Pentylenetetrazole
Phenobarbital
Principal components analysis
Resins
Signal transduction
Statistical analysis
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Summary:Epilepsy is a common clinical syndrome characterized by sudden and recurrent attacks and temporary central nervous system dysfunction caused by excessive discharge of neurons in the brain. Amber, a fossilized organic substance formed by the resins of conifers and leguminous plants, was prescribed to tranquilize the mind in China. In this paper, the antiepileptic effect of amber was evaluated by a pentylenetetrazole (PTZ)-induced epileptic model. An untargeted metabolomics approach was applied to investigate metabolic changes in the epileptic model, which was based on HILIC-UHPLC-MS/MS multivariate statistical analysis and metabolism network analysis. The outcome of this study suggested that 35 endogenous metabolites showed marked perturbations. Moreover, four metabolism pathways were mainly involved in epilepsy. After treatment by amber, the endogenous metabolites had a marked tendency to revert back to the situation of the control group which was consistent with phenobarbital. This study characterized the pentylenetetrazole-induced epileptic model and provided new evidence for the sedative effect of amber.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules24030460